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Creating an Annotated Biospecimen Resource for Liquid Biopsy Applications

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Circulating Tumor Cells

Part of the book series: Current Cancer Research ((CUCR))

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Abstract

The development and subsequent ready accessibility of an annotated, high-quality human biospecimen resource is essential for the validation of liquid biopsy biomarkers and technology platforms. In this chapter, we outline the critical components for creating a high-quality biospecimen resource including considerations for collection and minimizing pre-analytical variability, biospecimen processing, storage strategies, data annotation, and regulatory and administrative oversight. Additionally, reference is given to existing biospecimen resources that may be suitable for liquid biopsy research, when establishing such a resource de novo is impractical.

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Abbreviations

CAP:

College of American Pathologists

cfDNA:

Cell-free DNA

CHTN:

Cooperative Human Tissue Network

CTC:

Circulating tumor cell

DNA:

Deoxyribonucleic acid

EDRN:

Early Detection Research Network

EV:

Extracellular vesicle

ISBER:

International Society for Biological and Environmental Repositories

NCI:

National Cancer Institute

NCTN:

National Clinical Trials Network

PBMC:

Peripheral blood mononuclear cell

RBC:

Red blood cell

RNA:

Ribonucleic acid

WBC:

White blood cell

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Authors and Affiliations

  1. Department of Medicine, Harvard Medical School and Associate in Biostatistics (Medicine), Massachusetts General Hospital, Boston, MA, USA

    Steven J. Skates

  2. Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA

    Mark Watson

  3. Departments of Medicine, Biostatistics and Computational Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA

    David Elashoff

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Correspondence to Mark Watson .

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  1. Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA

    Richard J. Cote

  2. ACTC Lab, Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Athens, Greece

    Evi Lianidou

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Skates, S.J., Watson, M., Elashoff, D. (2023). Creating an Annotated Biospecimen Resource for Liquid Biopsy Applications. In: Cote, R.J., Lianidou, E. (eds) Circulating Tumor Cells. Current Cancer Research. Springer, Cham. https://doi.org/10.1007/978-3-031-22903-9_16

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