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Circadian Regulation of Sleep

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Sleep and Clocks in Aging and Longevity

Part of the book series: Healthy Ageing and Longevity ((HAL,volume 18))

Abstract

Among the circadian clock-controlled downstream processes and activities, the sleep–wake cycle ranks at the top as it displays the most overt daily changes. While the molecular genetic mechanism underlying the circadian clock has been largely elucidated, our understanding of sleep regulation, to some degree, remains ambiguous. It was posited that a circadian drive promotes sleep and wakefulness in a time-specific manner, while a homeostatic drive facilitates sleep. In this chapter, we focus on circadian roles in sleep, with a particular attention to the roles of circadian clock genes in sleep regulation. We also discuss the effects of circadian misalignment and sleep disorders on aging. It is emphasized that the neural and genetic pathways that link circadian input signals to the sleep output should be investigated in the future.

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Acknowledgements

The authors wish to thank the financial support from the National Key R&D Program of China (2019YFA0802400), the National Natural Science Foundation of China (NSFC) (#31961133026, #81570171, #81701347, #31871187, and #81070455), Jiangsu Province Science Foundation for Youths (BK20170351), and the Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions.

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  1. Center for Circadian Clocks, Soochow University, Suzhou, 215123, Jiangsu, China

    Zhaomin Zhong, Adeel Ahmed & Han Wang

  2. School of Biology & Basic Medical Sciences, Suzhou Medical College, Soochow University, Suzhou, 215123, Jiangsu, China

    Zhaomin Zhong, Adeel Ahmed & Han Wang

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  1. Zhaomin Zhong
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  2. Adeel Ahmed
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  3. Han Wang
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Correspondence to Han Wang .

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  1. Neurobiology and Molecular Chronobiology Laboratory, Department of Animal Biology, School of Life Science, University of Hyderabad, Hyderabad, Telangana, India

    Anita Jagota

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Zhong, Z., Ahmed, A., Wang, H. (2023). Circadian Regulation of Sleep. In: Jagota, A. (eds) Sleep and Clocks in Aging and Longevity. Healthy Ageing and Longevity, vol 18. Springer, Cham. https://doi.org/10.1007/978-3-031-22468-3_3

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