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Melatonin: A Saga of Health and Longevity

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Sleep and Clocks in Aging and Longevity

Part of the book series: Healthy Ageing and Longevity ((HAL,volume 18))

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Abstract

Melatonin, an indoleamine neurohormone produced during night-time from the pineal gland, is the master regulator of the circadian timing system and activity-rest rhythm in human beings. Melatonin is exceptional in exhibiting diverse biological roles and physiological functions and is involved in the alleviation of stress and regulation of various significant functions such as geroprotection, immunomodulation, energy metabolism, and cardiovascular health. Through its receptors and as a consequence of its receptor-independent functions melatonin also plays an important role in diseased conditions by having anti-neurodegenerative, anti-diabetic, and anti-osteoarthritic effects. In recent years, melatonin has gained much attention due to its potent antioxidant and anti-inflammatory properties which forms the basis of most of its preventive/protective effects. The present chapter reviews some of the aspects related to the protective role of melatonin concerning various pathologic conditions and explores the utility of dietary supplementation of plant-based phytomelatonin for health.

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Acknowledgments

The authors gratefully acknowledge the financial support provided in form of Start-up research grant by the University Grants Commission (UGC), New Delhi and Institute of Eminence (IoE), Banaras Hindu University, Varanasi, India.

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  1. Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, 221005, India

    Sameer Gupta, Amaresh Kumar Singh, Chandana Haldar & Anirban Roy

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Correspondence to Chandana Haldar .

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  1. Neurobiology and Molecular Chronobiology Laboratory, Department of Animal Biology, School of Life Science, University of Hyderabad, Hyderabad, Telangana, India

    Anita Jagota

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This article reviewed the published literature available in the domain with proper citations to the work of the original authors. This article does not contain any studies with human participants performed by any of the authors.

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© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG

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Gupta, S., Singh, A.K., Haldar, C., Roy, A. (2023). Melatonin: A Saga of Health and Longevity. In: Jagota, A. (eds) Sleep and Clocks in Aging and Longevity. Healthy Ageing and Longevity, vol 18. Springer, Cham. https://doi.org/10.1007/978-3-031-22468-3_15

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