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Pineal Gland Physiology and Aging-Related Alterations in the Circadian Timing System

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Sleep and Clocks in Aging and Longevity

Part of the book series: Healthy Ageing and Longevity ((HAL,volume 18))

Abstract

For the last few decades, multiple research groups have studied the various processes, mechanisms, and regulations that can be manipulated to slow down the aging process in both animals and humans. Melatonin, as well as epiphyseal proteins and peptides, have anti-aging properties. Chronobiologists have demonstrated that the biological rhythm of physiological functions is vital in aging control. It could be due to melatonin and these proteins’ ability to prevent cells from death while also maintaining immunocompetence and homeostasis. Changes in neuropeptides and neurohormone levels in the pineal glands and interactions with other endocrine secretions may be responsible for these tasks. This book chapter aims to outline some of these interdisciplinary findings related to pineal endocrine secretions, biological clocks, and aging.

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Author information

Authors and Affiliations

  1. DRDO-Defence Institute of High Altitude Research (DIHAR), Leh, UT Ladakh, 194101, India

    Vijay K. Bharti

  2. Somnogen Canada Inc, College Street, Toronto, ON, Canada

    Seithikurippu R. Pandi-Perumal

  3. Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India

    Seithikurippu R. Pandi-Perumal

  4. Department of Biochemistry and Biotechnology, Faculty of Science, Annmalai University, Chidambaram, Tamil Nadu, 608002, India

    Perumal Subramanian

Authors
  1. Vijay K. Bharti
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  2. Seithikurippu R. Pandi-Perumal
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  3. Perumal Subramanian
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Editor information

Editors and Affiliations

  1. Neurobiology and Molecular Chronobiology Laboratory, Department of Animal Biology, School of Life Science, University of Hyderabad, Hyderabad, Telangana, India

    Anita Jagota

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Bharti, V.K., Pandi-Perumal, S.R., Subramanian, P. (2023). Pineal Gland Physiology and Aging-Related Alterations in the Circadian Timing System. In: Jagota, A. (eds) Sleep and Clocks in Aging and Longevity. Healthy Ageing and Longevity, vol 18. Springer, Cham. https://doi.org/10.1007/978-3-031-22468-3_11

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