The Musculoskeletal System in Blood Diseases

Abstract

Multiple myeloma (MM) is a hematologic neoplasm due to malignant proliferation of plasma cells derived from a single clone. Plasma cell proliferation induced bone resorption causing diffused lytic lesions. The treatment of MM needs a multidisciplinary approach, including also radio- and chemotherapy. Sickle cell anaemia is an inherited haemoglobinopathy with bone lesions similar to those of thalassaemia syndromes. Thalassaemia syndromes are genetic alterations in the synthesis of α- or β-globin chains. Hodgkin’s lymphoma is a malignant lymphoma that can cause secondary manifestations at the skeletal level. Bone lesions in acute leukaemia occur more often in children and rarely in adults. Bone lesions during chronic leukaemia produce bony lesions less frequently compared to acute leukaemia. Haemophilia is a hereditary disease and is characterised by recurrent haemarthrosis in several joints.