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Which is the Cognitive Status of Patients with Epilepsy Undergoing Intracranial Presurgical Studies, and How is This Affected by Antiepileptic Drugs?

Part of the Studies in Neuroscience, Psychology and Behavioral Economics book series (SNPBE)

Abstract

Patients with drug-resistant focal epilepsy undergoing presurgical assessment may be cognitively impaired. Quality and intensity of these impairments differ inter- and even intraindividually. They may depend on patient variables (epileptogenic lesion, electric ictal and interictal activity, age and epilepsy duration) and iatrogenic interventions (anti-seizure medication and electrode implantation). This chapter will both summarize the most frequent cognitive impairments found in presurgical patients with epilepsy and illustrate factors influencing their cognitive status. A special focus will be laid on how antiepileptic drugs alter patients’ cognitive functioning. Finally, evidence on how these drugs may alter the signal of the intracranial EEG recording is reviewed. At the same time, we will discuss some practical implications based on this chapter’s clinical neuropsychological perspective for recording and interpreting experimental data in patients with epilepsy undergoing intracranial EEG assessment.

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Grewe, P., Bien, C.G. (2023). Which is the Cognitive Status of Patients with Epilepsy Undergoing Intracranial Presurgical Studies, and How is This Affected by Antiepileptic Drugs?. In: Axmacher, N. (eds) Intracranial EEG. Studies in Neuroscience, Psychology and Behavioral Economics. Springer, Cham. https://doi.org/10.1007/978-3-031-20910-9_2

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