Abstract
The hepatobiliary system consists of the liver, intrahepatic and extrahepatic bile ducts, and gallbladder. Fine needle aspiration specimens are obtained from the liver and, potentially, the gallbladder through image-guided percutaneous or endoscopic approaches. Intrahepatic bile duct epithelium is frequently identified in liver aspirate specimens while extrahepatic bile duct epithelium is more frequently evaluated by brushings obtained in endoscopic ultrasound-guided procedures and endoscopic retrograde cholangiopancreatography (ERCP). This chapter details the cytomorphologic spectrum of normal hepatocytes, biliary ductal cells, and gallbladder epithelium in a variety of cytologic preparations. The frequency and utility of cytologic evaluation in each of these organ sites is also highlighted.
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References
Molina KD, DiMaio VJM. Normal organ weights in men. Am J Forensic Med Pathol. 2012;33(4):368–72.
Molina KD, DiMaio VJM. Normal organ weights in women. Am J Forensic Med Pathol. 2015;36(3):182–7.
Bruix J, Sherman M. Management of hepatocellular carcinoma. Hepatology. 2005;42(3):1208–36.
Wang P, Meng AQ, Chen Z, et al. Diagnostic value and complications of fine needle aspiration for primary liver cancer and its influence on the treatment outcome: a study based on 3011 patients in China. Eur J Surg Oncol. 2008;34(5):541–6.
Lew M, Hissong EM, Westerhoff MA, Lamps LW. Optimizing small liver biopsy specimens: a combined cytopathology and surgical pathology perspective. J Am Soc Cytopathol. 2020;9(5):405–21.
Singhi AD, Jain D, Kakar S, Wu TT, Yeh MM, Torbsenson M. Reticulin loss in benign fatty liver: an important diagnostic pitfall when considering a diagnosis of hepatocellular carcinoma. Am J Surg Pathol. 2012;36(5):710–5.
Wee A. Diagnostic utility of immunohistochemistry in hepatocellular carcinoma, its variants and their mimics. Appl Immunohistochem Mol Morphol. 2016;14(3):266–72.
Yamamoto M, Nakajo S, Tahara E. Endocrine cells and lysozyme immunoreactivity in the gallbladder. Arch Pathol Lab Med. 1986;110(3):920–7.
Rana C, Krishnani N, Kumari N. Ultrasound-guided fine needle aspiration cytology of gallbladder lesions: a study of 596 cases. Cytopathology. 2016;27(6):398–406.
Yadav R, Jain D, Mathur SR, Sharma A, Iyer VK. Gallbladder carcinoma: an attempt of WHO histological classification on fine needle aspiration material. Cytojournal. 2013;10:12.
Chandra S, Chandra H, Shukla SK, Sahu S. Fine-needle aspiration cytology of gallbladder with an attempt of cytomorphological classification. Cytojournal. 2019;16:1.
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Lew, M. (2022). Hepatobiliary System. In: Lew, M., Pang, J., Pantanowitz, L. (eds) Normal Cytology. Springer, Cham. https://doi.org/10.1007/978-3-031-20336-7_4
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DOI: https://doi.org/10.1007/978-3-031-20336-7_4
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