Abstract
Malignant pleural mesothelioma is an infrequent neoplastic pathology; in Italy, about 1500 cases are diagnosed every year, and it is characterised by a poor prognosis. The first goal is to make a precise diagnosis. Cytological examination performed on the pleural fluid has a low diagnostic yield, of approximately 30%, and the correct diagnosis requires a biopsy. Thoracoscopic biopsy is considered the best diagnostic method in the most authoritative literature; it enables us to obtain a precise diagnosis in over 90% of cases.
Thoracoscopy, in addition to allowing for a precise diagnosis, contributes to the staging of mesothelioma, especially at the initial stages. At the same session, it is also possible to perform talc poudrage.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Pinto C, Novello S, Torri V, Ardizzoni A, Betta PG, Bertazzi PA, Casalini GA, Fava C, Fubini B, Magnani C, Mirabelli D, Papotti M, Ricardi U, Rocco G, Pastorino U, Tassi G, Trodella L, Zompatori M, Scagliotti G. Second Italian consensus conference on malignant pleural mesothelioma: state of the art and recommendations. Cancer Treat Rev. 2013;39(4):328–39. https://doi.org/10.1016/j.ctrv.2012.11.004. Epub 2012 Dec 12. PMID: 23244777.
Il Registro Nazionale Dei Mesoteliomi. Sesto Rapporto. INAIL 2018. Collana Ricerche.
Montanaro F, Rosato R, Gangemi M, Roberti S, Ricceri F, Merler E, Gennaro V, Romanelli A, Chellini E, Pascucci C, Musti M, Nicita C, Barbieri PG, Marinaccio A, Magnani C, Mirabelli D. Survival of pleural malignant mesothelioma in Italy: a population-based study. Int J Cancer. 2009;124(1):201–7. https://doi.org/10.1002/ijc.23874. PMID: 18792097.
Tassi GF, Marchetti GP. Il versamento pleurico neoplastico primitivo (mesotelioma pleurico). In: Casalini AG, editor. Pneumologia interventistica. Milano: Springer Italia; 2007.
Boutin C, Rey F. Thoracoscopy in pleural malignant mesothelioma: a prospective study of 188 consecutive patients. Part 1: diagnosis. Cancer. 1993;72(2):389–93. https://doi.org/10.1002/1097-0142(19930715)72:2<389::aid-cncr2820720213>3.0.co;2-v. PMID: 8319170.
Casalini AG, Melioli MPA, A, Rindi G, Lasagna L, Sabbadini F, Tafuro F, Bertorelli G. Mesotelioma maligno desmoplastico: presentazione di 4 casi clinici e breve revisione della letteratura. Rassegna Patol dell’Apparato Resp. 2011;26:18–23.
Scherpereel A, Astoul P, Baas P, Berghmans T, Clayson H, de Vuyst P, Dienemann H, Galateau-Salle F, Hennequin C, Hillerdal G, Le Péchoux C, Mutti L, Pairon JC, Stahel R, van Houtte P, van Meerbeeck J, Waller D, Weder W, European Respiratory Society/European Society of Thoracic Surgeons Task Force. Guidelines of the European Respiratory Society and the European Society of Thoracic Surgeons for the management of malignant pleural mesothelioma. Eur Respir J. 2010;35(3):479–95. https://doi.org/10.1183/09031936.00063109. Epub 2009 Aug 28. PMID: 19717482.
Novello S, Pinto C, Torri V, Porcu L, Di Maio M, Tiseo M, Ceresoli G, Magnani C, Silvestri S, Veltri A, Papotti M, Rossi G, Ricardi U, Trodella L, Rea F, Facciolo F, Granieri A, Zagonel V, Scagliotti G. The Third Italian consensus conference for malignant pleural mesothelioma: state of the art and recommendations. Crit Rev Oncol Hematol. 2016;104:9–20. https://doi.org/10.1016/j.critrevonc.2016.05.004. Epub 2016 May 13. PMID: 27286698.
Opitz I, Scherpereel A, Berghmans T, Psallidas I, Glatzer M, Rigau D, Astoul P, Bölükbas S, Boyd J, Coolen J, De Bondt C, De Ruysscher D, Durieux V, Faivre-Finn C, Fennell DA, Galateau-Salle F, Greillier L, Hoda MA, Klepetko W, Lacourt A, McElnay P, Maskell NA, Mutti L, Pairon JC, Van Schil P, van Meerbeeck JP, Waller D, Weder W, Putora PM, Cardillo G. ERS/ESTS/EACTS/ESTRO guidelines for the management of malignant pleural mesothelioma. Eur J Cardiothorac Surg. 2020;58(1):1–24. https://doi.org/10.1093/ejcts/ezaa158. PMID: 32448904.
Maskell NA, Gleeson FV, Davies RJ. Standard pleural biopsy versus CT-guided cutting-needle biopsy for diagnosis of malignant disease in pleural effusions: a randomised controlled trial. Lancet. 2003;361(9366):1326–30. https://doi.org/10.1016/s0140-6736(03)13079-6. PMID: 12711467.
American Thoracic Society. Diagnosis and initial management of nonmalignant diseases related to asbestos. Am J Respir Crit Care Med. 2004;170(6):691–715. https://doi.org/10.1164/rccm.200310-1436ST. PMID: 15355871.
Corradi M, Goldoni M, Alinovi R, Tiseo M, Ampollini L, Bonini S, Carbognani P, Casalini A, Mutti A. YKL-40 and mesothelin in the blood of patients with malignant mesothelioma, lung cancer and asbestosis. Anticancer Res. 2013;33(12):5517–24. PMID: 24324091.
Nowak AK. CT, RECIST, and malignant pleural mesothelioma. Lung Cancer. 2005;49(Suppl 1):S37–40. https://doi.org/10.1016/j.lungcan.2005.03.030. Epub 2005 Apr 20. PMID: 15950799.
Gelzinis TA. The 2019 ERS/ESTS/EACTS/ESTRO guidelines on the management of patients with malignant pleural mesothelioma. J Cardiothorac Vasc Anesth. 2021;35(2):378–88. https://doi.org/10.1053/j.jvca.2020.07.017. Epub 2020 Jul 30. PMID: 32798169.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this chapter
Cite this chapter
Casalini, A.G. (2023). Malignant Pleural Mesothelioma. In: Casalini, A.G. (eds) Practical Manual of Pleural Pathology. Springer, Cham. https://doi.org/10.1007/978-3-031-20312-1_4
Download citation
DOI: https://doi.org/10.1007/978-3-031-20312-1_4
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-031-20311-4
Online ISBN: 978-3-031-20312-1
eBook Packages: MedicineMedicine (R0)