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Evaluation and Management of Patients with Left Ventricular Assist Device (LVAD) Requiring Noncardiac SurgicalProcedures

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The High-risk Surgical Patient

Abstract

The introduction of left ventricular assist device (LVAD) has improved survival rates for patients with end-stage heart failure. Survival rate at one year with the latest generation of continuous flow (CF) LVAD now approaches 80%. They have been approved suitable as a destination therapy (DT) in patients who were not eligible for transplantation. As a result, the LVAD population is growing, and the need for noncardiac surgical procedures (NCSs) in these patients will continue to rise. The anesthesiologist needs to be familiar with these particular types of patients and with these devices. The aim of this chapter is to highlight the devices’ characteristics, the LVAD patients’ hemodynamic profile, and the most frequent complications, together with an overview on how to approach these patients when they present for elective or emergency NCS.

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References

  1. Ambrosy AP, Fonarow GC, Butler J, Chioncel O, Greene SJ, Vaduganathan M, Gheorghiade M. The global health and economic burden of hospitalizations for heart failure: Lessons learned from hospitalized heart failure registries. J Am Coll Cardiol. 2014;63(12):1123–33.

    Article  PubMed  Google Scholar 

  2. Metra M, Ponikowski P, Dickstein K, McMurray JJV, Gavazzi A, Bergh CH, et al. Advanced chronic heart failure: a position statement from the Study Group on Advanced Heart Failure of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail. 2007;9(6–7):684–94. https://doi.org/10.1016/j.ejheart.2007.04.003.

    Article  PubMed  Google Scholar 

  3. Ammirati E, Oliva FG, Colombo T, Russo CF, Cipriani MG, Garascia A, et al. Mid-term survival after continuous-flow left ventricular assist device versus heart transplantation. Heart Vessels. 2016;31(5):722–33. https://doi.org/10.1007/s00380-015-0654-4.

    Article  PubMed  Google Scholar 

  4. Rose EA, Gelijns AC, Moskowitz AJ, Heitjan DF, Stevenson LW, Dembitsky W, Long JW, Ascheim D, Tierney A, et al. Long-Term Use of a Left Ventricular Assist Device. N Engl J Med. 2001;345(20):1435–43.

    Article  CAS  PubMed  Google Scholar 

  5. Kormos RL, Cowger J, Pagani FD, Teuteberg JJ, Goldstein DJ, Jacobs JP, et al. The Society of Thoracic Surgeons Intermacs database annual report: evolving indications, outcomes, and scientific partnerships. J Heart Lung Transplant. 2019;38(2):114–26. https://doi.org/10.1016/j.healun.2018.11.013.

    Article  PubMed  Google Scholar 

  6. Molina EJ, Shah P, Kiernan MS, Cornwell WK, Copeland H, Takeda K, et al. The Society of Thoracic Surgeons Intermacs 2020 annual report. Ann Thorac Surg. 2021;111(3):778–92. https://doi.org/10.1016/j.athoracsur.2020.12.038.

    Article  PubMed  Google Scholar 

  7. Morgan JA, Paone G, Nemeh HW, Henry SE, Gerlach B, Williams CT, et al. Non-cardiac surgery in patients on long-term left ventricular assist device support. J Heart Lung Transplant. 2012;31(7):757–63. https://doi.org/10.1016/j.healun.2012.02.023. Left Ventricular Assist Devices

    Article  PubMed  Google Scholar 

  8. Vaidya Y, Riaz S, Dhamoon AS. Left ventricular assist devices. Treasure Island (FL): StatPearls Publishing; 2021. https://www.ncbi.nlm.nih.gov/books/NBK499841/?report

    Google Scholar 

  9. Miller LW, Rogers JG. Evolution of left ventricular assist device therapy for advanced heart failure: a review. JAMA Cardiol. 2018;3(7):650–8. https://doi.org/10.1001/jamacardio.2018.0522.

    Article  PubMed  Google Scholar 

  10. Potapov EV, Antonides C, Crespo-Leiro MG, Combes A, Färber G, Hannan MM, et al. 2019 EACTS Expert Consensus on long-term mechanical circulatory support. Eur J Cardiothorac Surg. 2019;56(2):230–70. https://doi.org/10.1093/ejcts/ezz098.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Kuehl M, Garbade J. The evolution of left ventricular assist devices—a moment to reflect. J Thorac Dis. 2017;9(5):E492–4. https://doi.org/10.21037/jtd.2017.03.72.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Mehra MR, Uriel N, Naka Y, Cleveland JC, Yuzefpolskaya M, Salerno CT, et al. A fully magnetically levitated left ventricular assist device—final report. N Engl J Med. 2019;380(17):1618–27. https://doi.org/10.1056/nejmoa1900486.

    Article  PubMed  Google Scholar 

  13. Lim HS, Howell N, Ranasinghe A. The physiology of continuous-flow left ventricular assist devices. J Card Fail. 2017;23(2):169–80. https://doi.org/10.1016/j.cardfail.2016.10.015.

    Article  PubMed  Google Scholar 

  14. Paprotny M, Ruschitzka F, Lüders B, Wilhelm MJ, Aser R, Bettex D, et al. Pulsatile arterial blood pressure mimicking aortic valve opening during continuous-flow LVAD support: a case report. J Cardiothorac Surg. 2019;14(1):1–4. https://doi.org/10.1186/s13019-019-1039-z.

    Article  Google Scholar 

  15. Dalia AA, Cronin B, Stone ME, Turner K, Hargrave J, Vidal Melo MF, Essandoh M. Anesthetic management of patients with continuous-flow left ventricular assist devices undergoing noncardiac surgery: an update for anesthesiologists. J Cardiothorac Vasc Anesth. 2018;32(2):1001–12. https://doi.org/10.1053/j.jvca.2017.11.038.

    Article  PubMed  Google Scholar 

  16. Patel SR, Madan S, Saeed O, Algodi M, Luke A, Gibber M, et al. Association of nasal mucosal vascular alterations, gastrointestinal arteriovenous malformations, and bleeding in patients with continuous-flow left ventricular assist devices. JACC Heart Failure. 2016;4(12):962–70. https://doi.org/10.1016/j.jchf.2016.08.005.

    Article  PubMed  Google Scholar 

  17. Feldman D, Pamboukian SV, Teuteberg JJ, Birks E, Lietz K, Moore SA, et al. The 2013 International Society for Heart and Lung Transplantation Guidelines for mechanical circulatory support: Executive summary. J Heart Lung Transplant. 2013;32(2):157–87. https://doi.org/10.1016/j.healun.2012.09.013.

    Article  PubMed  Google Scholar 

  18. Vader JM, Ewald GA, Gage BF. Relationship between anticoagulation intensity and thrombotic or bleeding outcomes amongst. 2017;9(5):1–19. Ventricular Assist Devices. Circ Heart Fail. 2016;9(5):e002680. https://doi.org/10.1161/CIRCHEARTFAILURE.115.002680. https://doi.org/10.1161/CIRCHEARTFAILURE.115.002680.RELATIONSHIP

  19. Inamullah O, Chiang YP, Bishawi M, Weiss M, Lutz MW, Blue LJ, et al. Characteristics of strokes associated with centrifugal flow left ventricular assist devices. Sci Rep. 2021;11(1):1–9. https://doi.org/10.1038/s41598-021-81445-8.

    Article  CAS  Google Scholar 

  20. Mathis M. Complications, risk factors, and staffing patterns for noncardiac surgery in patients with left ventricular assist devices. Anesthesiology. 2017;126(3):450–60. https://doi.org/10.1097/ALN.0000000000001488.

    Article  PubMed  Google Scholar 

  21. Kettyle SM, Chervu NL, Rao AS, Sadi S, Majure D, Sava JA, Johnson LS. Outcomes following noncardiac surgery in patients with ventricular assist devices: a single-center experience. Am Surg. 2017;83(8):842–6. https://doi.org/10.1177/000313481708300833.

    Article  PubMed  Google Scholar 

  22. Bauman ZM, Cunningham R, Hodson A, Shostrom V, Evans CH, Schlitzkus LL. Emergent general surgery operations in patients with left ventricular assist devices. Am Surg. 2021;87:8–14. https://doi.org/10.1177/0003134820950683.

    Article  PubMed  Google Scholar 

  23. Davis J, Sanford D, Schilling J, Hardi A, Colditz G. Systematic review of outcomes after noncardiac surgery in patients with implanted left ventricular assist devices. ASAIO J. 2015;61(6):648–51. https://doi.org/10.1097/MAT.0000000000000278.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Taghavi S, Jayarajan SN, Ambur V, Mangi AA, Chan E, Dauer E, et al. Noncardiac surgical procedures after left ventricular assist device implantation. ASAIO J. 2016;62(4):370–4. https://doi.org/10.1097/MAT.0000000000000366.

    Article  PubMed  Google Scholar 

  25. Mentias A, Briasoulis A, Vaughan Sarrazin MS, Alvarez PA. Trends, perioperative adverse events, and survival of patients with left ventricular assist devices undergoing noncardiac surgery. JAMA Netw Open. 2020;3(11):1–11. https://doi.org/10.1001/jamanetworkopen.2020.25118.

    Article  Google Scholar 

  26. Vigneswaran Y, Wang V, Krezalek M, Prachand V, Wyers S, Juricek C, et al. Laparoscopic procedures in patients with cardiac ventricular assist devices. Surg Endosc. 2019;33(7):2181–6. https://doi.org/10.1007/s00464-018-6497-1.

    Article  PubMed  Google Scholar 

  27. Moazami N, Fukamachi K, Kobayashi M, Smedira NG, Hoercher KJ, Massiello A, et al. Axial and centrifugal continuous-flow rotary pumps: a translation from pump mechanics to clinical practice. J Heart Lung Transplant. 2013;32(1):1–11. https://doi.org/10.1016/j.healun.2012.10.001.

    Article  PubMed  Google Scholar 

  28. Lampert BC, Teuteberg JJ. Right ventricular failure after left ventricular assist devices. J Heart Lung Transplant. 2015;34(9):1123–30. https://doi.org/10.1016/j.healun.2015.06.015.

    Article  PubMed  Google Scholar 

  29. Kirklin JK, Naftel DC, Pagani FD, Kormos RL, Stevenson LW, Blume ED, et al. Sixth INTERMACS annual report: a 10,000-patient database. J Heart Lung Transplant. 2014;33(6):555–64.

    Article  PubMed  Google Scholar 

  30. Rosenman DJ, McDonald FS, Ebbert JO, Erwin PJ, LaBella M, Montori VM. Clinical consequences of withholding versus administering renin-angiotensin-aldosterone system antagonists in the preoperative period. J Hosp Med. 2008;3(4):319–25. https://doi.org/10.1002/jhm.323.

    Article  PubMed  Google Scholar 

  31. Kristensen SD, Knuuti J, Saraste A, Anker S, Bøtker HE, De Hert S, et al. 2014 ESC/ESA guidelines on non-cardiac surgery: cardiovascular assessment and management: the joint task force on non-cardiac surgery: cardiovascular assessment and management of the European Society of Cardiology (ESC) and the European Society of Anaesthesiology (ESA). Eur Heart J. 2014;35(35):2383–431. https://doi.org/10.1093/eurheartj/ehu282.

    Article  PubMed  Google Scholar 

  32. El-Magharbel I. Ventricular assist devices and anesthesia. Semin Cardiothorac Vasc Anesth. 2005;9(3):241–9. https://doi.org/10.1177/108925320500900306.

    Article  PubMed  Google Scholar 

  33. Stoicea N, Sacchet-Cardozo F, Joseph N, Kilic A, Sipes A, Essandoh M. Pro: cardiothoracic anesthesiologists should provide anesthetic care for patients with ventricular assist devices undergoing noncardiac surgery. J Cardiothorac Vasc Anesth. 2017;31(1):378–81. https://doi.org/10.1053/j.jvca.2016.06.030.

    Article  PubMed  Google Scholar 

  34. Rich JD, Burkhoff D. HVAD flow waveform morphologies: theoretical foundation and implications for clinical practice. ASAIO J. 2017;63(5):526–35. https://doi.org/10.1097/MAT.0000000000000557.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Ficke DJ, Lee J, Chaney MA, Bas H, Vidal-Melo MF, Stone ME. Case 62010 noncardiac surgery in patients with a left ventricular assist device. J Cardiothorac Vasc Anesth. 2010;24(6):1002–9. https://doi.org/10.1053/j.jvca.2010.09.005.

    Article  PubMed  Google Scholar 

  36. Slaughter MS, Pagani FD, Rogers JG, Miller LW, Sun B, Russell SD, et al. Clinical management of continuous-flow left ventricular assist devices in advanced heart failure. J Heart Lung Transplant. 2010;29(4 SUPPL):S1–S39. https://doi.org/10.1016/j.healun.2010.01.011.

    Article  PubMed  Google Scholar 

  37. Essandoh M, Shabsigh M, Turner M, Otey A, Poulton C, Fiorda-Diaz J, Kilic A. Heartmate II inflow path thrombosis: emphasis on a comprehensive approach to diagnosis. J Cardiothorac Vasc Anesth. 2017;31(3):1015–20. https://doi.org/10.1053/j.jvca.2016.08.005.

    Article  PubMed  Google Scholar 

  38. Barbara DW, Wetzel DR, Pulido JN, Pershing BS, Park SJ, Stulak JM, et al. The perioperative management of patients with left ventricular assist devices undergoing noncardiac surgery. Mayo Clin Proc. 2013;88(7):674–82. https://doi.org/10.1016/j.mayocp.2013.03.019.

    Article  PubMed  Google Scholar 

  39. Peberdy MA, Gluck JA, Ornato JP, Bermudez CA, Griffin RE, Kasirajan V, et al. Cardiopulmonary resuscitation in adults and children with mechanical circulatory support: a scientific statement from the American Heart Association. Circulation. 2017;135(24):e1115–34. https://doi.org/10.1161/CIR.0000000000000504.

    Article  PubMed  Google Scholar 

  40. Aissaoui N, Jouan J, Gourjault M, Diebold B, Ortuno S, Hamdan A, et al. Understanding left ventricular assist devices. Blood Purif. 2018;46(4):292–300. https://doi.org/10.1159/000491872.

    Article  PubMed  Google Scholar 

  41. Kamboj M, Kazory A. Left ventricular assist device and the kidney: getting to the heart of the matter. Blood Purif. 2019;48(4):289–98. https://doi.org/10.1159/000502080.

    Article  PubMed  Google Scholar 

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Correspondence to Michele G. Mondino .

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Mondino, M.G., Paradiso, E., Nonini, S. (2023). Evaluation and Management of Patients with Left Ventricular Assist Device (LVAD) Requiring Noncardiac SurgicalProcedures. In: Aseni, P., Grande, A.M., Leppäniemi, A., Chiara, O. (eds) The High-risk Surgical Patient. Springer, Cham. https://doi.org/10.1007/978-3-031-17273-1_37

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  • DOI: https://doi.org/10.1007/978-3-031-17273-1_37

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