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Clinical Features of Diabetes Neuropathies

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Diabetic Neuropathy

Part of the book series: Contemporary Diabetes ((CDI))

Abstract

Diabetic polyneuropathy affects 50% of patients with diabetes mellitus. It encompasses several neuropathic syndromes, the commonest being distal symmetrical polyneuropathy or ‘diabetic peripheral neuropathy’ (DPN). Risk factors for DPN include poor glycaemic control and drivers of macrovascular disease including hypertension, smoking, and obesity. Strong evidence in humans and animals implicates nerve ischaemia as the cause of DPN. Despite several well-designed recent trials, no novel approved treatment with unequivocal effects on the decline in nerve function in DPN has emerged. Painful DPN affects about a quarter of those with diabetes and produces considerable disability and is challenging to assess and manage. Diabetic autonomic neuropathy also results in considerable morbidity, reduced quality of life, and increased mortality. It may involve cardiovascular, gastrointestinal, urogenital, pupillomotor, thermoregulatory, and sudomotor function.

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Author information

Authors and Affiliations

  1. Diabetes Research Unit, Sheffield Teaching Hospitals Trust and the University of Sheffield, Sheffield, UK

    Gordon Sloan

  2. Department of Endocrinology, National Center of Gerontology, Beijing Hospital, Beijing, China

    Qi Pan & Lixin Guo

  3. Department of Endocrinology and Metabolism, Renmin Hospital of Wuhan University, Wuhan, China

    Ling Gao

  4. Diabetes Research Unit, Sheffield Teaching Hospitals and the University of Sheffield, Sheffield, UK

    Solomon Tesfaye

Authors
  1. Gordon Sloan
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  2. Qi Pan
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  3. Ling Gao
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  4. Lixin Guo
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  5. Solomon Tesfaye
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Corresponding author

Correspondence to Solomon Tesfaye .

Editor information

Editors and Affiliations

  1. Royal Hallamshire Hospital, Sheffield Teaching Hospitals and the University of Sheffield Director of Diabetes Research, Sheffield, UK

    Solomon Tesfaye

  2. Beth Israel Deaconess Medical Center, Boston, MA, USA

    Christopher H. Gibbons

  3. Weill Cornell Medicine, Cornell University, Doha, Qatar

    Rayaz Ahmed Malik

  4. Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA

    Aristidis Veves

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© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG

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Sloan, G., Pan, Q., Gao, L., Guo, L., Tesfaye, S. (2023). Clinical Features of Diabetes Neuropathies. In: Tesfaye, S., Gibbons, C.H., Malik, R.A., Veves, A. (eds) Diabetic Neuropathy. Contemporary Diabetes. Humana, Cham. https://doi.org/10.1007/978-3-031-15613-7_3

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  • DOI: https://doi.org/10.1007/978-3-031-15613-7_3

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  • Publisher Name: Humana, Cham

  • Print ISBN: 978-3-031-15612-0

  • Online ISBN: 978-3-031-15613-7

  • eBook Packages: MedicineMedicine (R0)

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