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Visceral Sensitivity

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Pediatric Neurogastroenterology

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Abstract

The gastrointestinal (GI) tract has a rich afferent innervation that can detect mechanical, chemical, and thermal stimuli. Sensory information reaching the cortex can give rise to conscious sensations, painful or not. Abnormal heightened visceral sensitivity may lead to functional gastrointestinal disorders, and visceral hypersensitivity is considered a crucial pathophysiological factor. This chapter covers the description of the sensory innervation of the GI tract and the pathways followed in the central nervous system. The physiology of visceral sensitivity and the mechanisms leading to visceral hypersensitivity in children and adults are also described and discussed.

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Acknowledgments

I would like to acknowledge the work of Dr. Christophe Faure, who wrote the prior version of this chapter.

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Authors and Affiliations

  1. Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Medical College of Wisconsin, Milwaukee, WI, USA

    Adrian Miranda

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  1. Division of Gastroenterology, Department of Pediatrics, Centre Hospitalier Universitaire Sainte-Justine, University of Montreal, Montreal, QC, Canada

    Christophe Faure

  2. Department of Gastroenterology, Hepatology and Liver Transplant, Queensland Children’s Hospital School of Medicine University of Queensland, Brisbane, QLD, Australia

    Nikhil Thapar

  3. Division of Pediatric Gastroenterology, Nationwide Children’s Hospital, Columbus, OH, USA

    Carlo Di Lorenzo

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Miranda, A. (2022). Visceral Sensitivity. In: Faure, C., Thapar, N., Di Lorenzo, C. (eds) Pediatric Neurogastroenterology. Springer, Cham. https://doi.org/10.1007/978-3-031-15229-0_4

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