Abstract
Nongonococcal urethritis (NGU) is the commonest form of urethritis in developed countries and can be caused by a variety of infectious agents as well as noninfectious conditions. Chlamydia trachomatis is the pathogen identified more frequently, followed by Mycoplasma genitalium. NGU may be asymptomatic or cause mild to moderate irritation, but if left untreated it can result in serious complications. Patients with symptoms or signs of urethritis should undergo testing with a Gram-stained urethral swab or first-pass urine specimen; cases with confirmed or suspected urethritis should consequently be tested for N. gonorrhoeae and C. trachomatis. Treatment of NGU includes therapeutic schemes that are effective against C. trachomatis, STD counseling and monitoring, patient follow-up, and proper management of sexual contacts. Persistent and recurrent NGU occurs in 10–20% of cases and should be treated accordingly.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Further Reading
Braam JF, van Dommelen L, Henquet CJM, van de Bovenkamp JHB, Kusters JG. Multidrug-resistant mycoplasma genitalium infections in Europe. Eur J Clin Microbiol Infect Dis. 2017;36:1565–7. https://doi.org/10.1007/s10096-017-2969-9.
Horner P, Thomas B, Gilroy CB, Egger M, Taylor-Robinson D. Role of mycoplasma genitalium and Ureaplasma urealyticum in acute and chronic nongonococcal urethritis. Clin Infect Dis. 2001;32:995–1003.
Horner PJ, Blee K, Falk L, van der Meijden W, Moi H. 2016 European guideline on the management of non-gonococcal urethritis. Int J STD AIDS. 2016;27:928–37. https://doi.org/10.1177/0956462416648585.
Horner PJ, Martin DH. Mycoplasma genitalium infection in men. J Infect Dis. 2017;216(suppl_2):S396–405.
Jensen JS, Bjornelius E, Dohn B, Lidbrink P. Comparison of first void urine and urogenital swab specimens for detection of mycoplasma genitalium and chlamydia trachomatis by polymerase chain reaction in patients attending a sexually transmitted disease clinic. Sex Transm Dis. 2004;31:499–507.
Jernberg E, Moghaddam A, Moi H. Azithromycin and moxifloxacin for microbiological cure of mycoplasma genitalium infection: an open study. Int J STD AIDS. 2008;19:676–9.
Lanjouw E, Ouburg S, de Vries HJ, Stary A, Radcliffe K, Unemo M. 2015 European guideline on the management of chlamydia trachomatis infections. Int J STD AIDS. 2016;27:333–48. https://doi.org/10.1177/0956462415618837.
Martin DH. Nongonococcal urethritis: new views through the prism of modern molecular microbiology. Curr Infect Dis Rep. 2008;10:128–32.
Mena L, Mroczkowsky TF, Nsuami M, Martin DH. A randomized comparison of azithromycin and doxycycline for the treatment of mycoplasma genitalium (MG) positive urethritis in men. Clin Infect Dis. 2009;48:1649–54.
Workowski KA, Bolan GA, Centers for Disease Control and Prevention (CDC). Sexually transmitted diseases treatment guidelines, 2015 [published correction appears in MMWR Recomm rep. 2015;64(33):924]. MMWR Recomm Rep. 2015;64(RR-03):1–137.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2023 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Stefanaki, I. (2023). Urethritis: Nongonococcal. In: Katsambas, A.D., Lotti, T.M., Dessinioti, C., D'Erme, A.M. (eds) European Handbook of Dermatological Treatments. Springer, Cham. https://doi.org/10.1007/978-3-031-15130-9_99
Download citation
DOI: https://doi.org/10.1007/978-3-031-15130-9_99
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-031-15129-3
Online ISBN: 978-3-031-15130-9
eBook Packages: MedicineMedicine (R0)