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Drug Photosensitivity

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European Handbook of Dermatological Treatments

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Abstract

Drug photosensitivity is a relatively frequent adverse event, although not always recognized due to its clinical polymorphism and difficulties in performing tests to prove drug causality.

In this chapter the authors review the mechanisms of photosensitivity related with topical and systemic drug exposure (phototoxicity, photoallergy, autoimmunity, and enhanced photocarcinogenesis), the main acute and delayed clinical manifestations (acute sunburn or eczema, pseudoporphyria, photoonycholysis, dyschromia, telangiectasia, subacute lupus erythematosus, pre-cancerous lesions, and cutaneous neoplasia), the main culprits (NSAIDs, antimicrobials, like fluorquinolones and tetracyclines, psychotropic, anticancer, and cardiovascular drugs), and the most adequate diagnostic procedures (photopatch and drug photoprovocation tests).

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Authors and Affiliations

  1. Clinic of Dermatology, University Hospital and Faculty of Medicine, University of Coimbra, Coimbra, Portugal

    Margarida Gonçalo

  2. Department of Dermatology, Hospital del Mar. Universitat Autonoma y Universitat Pompeu Fabra. Barcelona, Barcelona, Spain

    Ana Giménez-Arnau

Authors
  1. Margarida Gonçalo
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  2. Ana Giménez-Arnau
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Correspondence to Margarida Gonçalo .

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Editors and Affiliations

  1. Andreas Syggros Hospital, Athens State University, Athens, Greece

    Andreas D. Katsambas

  2. Research Center CSRMR, Marconi University, Rome, Roma, Italy

    Torello M. Lotti

  3. Andreas Syggros Hospital, Athens State University, Athens, Greece

    Clio Dessinioti

  4. Dermatoloy Unit, Livorno Hospital, Livorno, Italy

    Angelo Massimiliano D'Erme

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Gonçalo, M., Giménez-Arnau, A. (2023). Drug Photosensitivity. In: Katsambas, A.D., Lotti, T.M., Dessinioti, C., D'Erme, A.M. (eds) European Handbook of Dermatological Treatments. Springer, Cham. https://doi.org/10.1007/978-3-031-15130-9_23

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  • DOI: https://doi.org/10.1007/978-3-031-15130-9_23

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