Abstract
Chimeric antigen receptor T-cell therapy is a form of adoptive immunotherapy that is promising for the treatment of hematologic malignancies. Solve it!
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References
Zhang H, Zhao P, Huang H. Engineering better chimeric antigen receptor T cells. Exp Hematol Oncol. 2020;9:34. https://doi.org/10.1186/s40164-020-00190-2.
Feins S, Kong W, Williams EF, Milone MC, Fraietta JA. An introduction to chimeric antigen receptor (CAR) T-cell immunotherapy for human cancer. Am J Hematol. 2019;94(S1):S3–9.
Lana MG, Strauss BE. Production of lentivirus for the establishment of CAR-T cells. Methods Mol Biol. 2020;2086:61–7.
Holmes B. CAR T-cell therapy indications grow significantly in 2021. Targeted Ther Oncol. 2021;10(8):10. https://www.targetedonc.com/view/car-t-cell-therapy-indications-grow-significantly-in-2021
Neelapu SS, Locke FL, Bartlett NL, Lekakis LJ, Miklos DB, Jacobson CA, et al. Axicabtagene ciloleucel CAR T-cell therapy in refractory large B-cell lymphoma. N Engl J Med. 2017;377(26):2531–44.
Aamir S, Anwar MY, Khalid F, Khan SI, Ali MA, Khattak ZE. Systematic review and meta-analysis of CD19-specific CAR-T cell therapy in relapsed/refractory acute lymphoblastic leukemia in the pediatric and young adult population: safety and efficacy outcomes. Clin Lymphoma Myeloma Leuk. 2021;21(4):e334–7.
Maude SL, Laetsch TW, Buechner J, Rives S, Boyer M, Bittencourt H, et al. Tisagenlecleucel in children and young adults with B-cell lymphoblastic leukemia. N Engl J Med. 2018;378(5):439–48.
Marofi F, Motavalli R, Safonov VA, et al. CAR T cells in solid tumors: challenges and opportunities. Stem Cell Res Ther. 2021;12:81. https://doi.org/10.1186/s13287-020-02128-1.
Novartis Pharmaceuticals Corp. KYMRIAH® prescribing information. East Hanover: Novartis Pharmaceuticals Corp.; 2020.
Kite Pharma, Inc. YESCARTA® prescribing information. Santa Monica: Kite Pharma, Inc.; 2022.
Kite Pharma, Inc. TECARTUS® prescribing information. Santa Monica: Kite Pharma, Inc.; 2021.
Celgene Corp. ABECMA® prescribing information. Summit: Celgene Corp.; 2021.
Juno Therapeutics, Inc. BREYANZI® prescribing information. Bothell: Juno Therapeutics, Inc.; 2021.
Allen ES, Stroncek DF, Ren J, Eder AF, West KA, Fry TJ, et al. Autologous lymphapheresis for the production of chimeric antigen receptor T cells. Transfusion. 2017;57(5):1133–41.
Korell F, Laier S, Sauer S, Veelken K, Hennemann H, Schubert M-L, et al. Current challenges in providing good leukapheresis products for manufacturing of CAR-T cells for patients with relapsed/refractory NHL or ALL. Cell. 2020;9(5):1225.
Further Reading
Feins S, Kong W, Williams EF, Milone MC, Fraietta JA. An introduction to chimeric antigen receptor (CAR) T-cell immunotherapy for human cancer. Am J Hematol. 2019;94(S1):S3–9.
Kuldanek S, Pasko B, DomBourian M, Annen K. Cellular therapy in pediatric hematologic malignancies. Clin Lab Med. 2021;41(1):121–32.
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Friedman, M.T., West, K.A., Bizargity, P., Annen, K., Gur, H.D., Hilbert, T. (2023). “CAR T”-esian Thinking. In: Immunohematology, Transfusion Medicine, Hemostasis, and Cellular Therapy. Springer, Cham. https://doi.org/10.1007/978-3-031-14638-1_95
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DOI: https://doi.org/10.1007/978-3-031-14638-1_95
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