Abstract
The Kleihauer-Betke acid elution test is commonly used to assess fetal-maternal hemorrhage in pregnant women through the detection of fetal hemoglobin. Yet, conditions other than fetal-maternal hemorrhage may affect fetal hemoglobin levels. Solve it!
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References
Karafin MS, Glisch C, Souers RJ, Hudgins J, Park YA, Ramsey GE, et al. Use of fetal hemoglobin quantitation for Rh-positive pregnant females. Arch Pathol Lab Med. 2019;143:1539–44.
Audette MC, Mclean K, Malkani N, Kingdom J, Sobel M. Diagnostic accuracy of Kleihauer–Betke (Kb) testing to predict fetal outcomes associated with fetomaternal hemorrhage: a retrospective cohort study. J Perinatol. 2022;42:91–6. 18 August. https://www.nature.com/articles/s41372-021-01185-5.pdf?proof=t. Accessed 20 Oct 2021.
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Further Reading
Atkinson AL, Santolaya-Forgas J, Matta P, Canterino J, Oyelese Y. The sensitivity of the Kleihauer-Betke test for placental abruption. J Obstet Gynaecol. 2015;35(2):139–41.
Audette MC, Mclean K, Malkani N, Kingdom J, Sobel M. Diagnostic accuracy of Kleihauer–Betke (Kb) testing to predict fetal outcomes associated with fetomaternal hemorrhage: a retrospective cohort study. J Perinatol. 2022;42:91–6. https://www.nature.com/articles/s41372-021-01185-5.pdf?proof=t.
Fucharoen S, Winichagoon P. Haemoglobinopathies in southeast Asia. Indian J Med Res. 2011;134(4):498–506.
Karafin MS, Glisch C, Souers RJ, Hudgins J, Park YA, Ramsey GE, et al. Use of fetal hemoglobin quantitation for Rh-positive pregnant females. Arch Pathol Lab Med. 2019;143:1539–44.
Vichinsky E. Hemoglobin E syndromes. Hematol Am Soc Educ Program. 2007;2007(1):79–83.
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Friedman, M.T., West, K.A., Bizargity, P., Annen, K., Gur, H.D., Hilbert, T. (2023). KB Conundrum. In: Immunohematology, Transfusion Medicine, Hemostasis, and Cellular Therapy. Springer, Cham. https://doi.org/10.1007/978-3-031-14638-1_82
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