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Abstract

Necrotizing enterocolitis is a multifactorial disorder that is relatively common in premature very low birth weight neonates. A proportion of such cases has been linked to red blood cell transfusion, though the exact mechanism is unclear. Solve it!

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References

  1. Wong ECC, Punzalan RC. Neonatal and pediatric transfusion practice. In: Cohn CS, Delaney M, Johnson ST, Katz LM, editors. Technical manual. 20th ed. Bethesda: AABB; 2020. p. 678–80.

    Google Scholar 

  2. Gephart SM. Transfusion-associated necrotizing enterocolitis: evidence and uncertainty. Adv Neonatal Care. 2012;12(4):232–6.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Blau J, Calo JM, Dozor D, Sutton M, Alpan G, LaGamma EF. Transfusion-related acute gut injury: necrotizing enterocolitis in very low birth weight neonates after packed red blood cell transfusion. J Pediatr. 2011;158(3):403–9.

    Article  PubMed  Google Scholar 

  4. Sesok-Pizzini DA, Vossoughi S. Complications of neonatal transfusion. In: Kopko PM, editor. Transfusion reactions. 5th ed. Bethesda: AABB Press; 2021. p. 489–91.

    Google Scholar 

  5. Stokes V, Rajal A, Mukherjee D, Mukherjee A. Transfusion-associated necrotizing enterocolitis (NEC) in extremely preterm infants: experience of a tertiary neonatal center in UK. J Matern Fetal Neonatal Med. 2021. https://www.tandfonline.com/doi/full/10.1080/14767058.2021.1874910?scroll=top&needAccess=true. Accessed 30 Sept 2021.

  6. LaGamma EF. Do transfusions cause necrotizing enterocolitis? Evidence and potential mechanisms. Breastfeed Med. 2018;13(S1):S-20–2.

    Article  Google Scholar 

  7. Schindler T, Yeo KT, Bolisetty S, Michalowski J, Tan AHK, Lui K. FEEding DURing red cell transfusion (FEEDUR RCT): a multi-arm randomised controlled trial. BMC Pediatr. 2020;20:346.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Centers for Disease Control and Prevention. National healthcare safety network biovigilance component, hemovigilance module surveillance protocol v2.6, Atlanta, GA. March 2021. https://www.cdc.gov/nhsn/PDFs/Biovigilance/BV-HV-protocol-current.pdf. Accessed 4 Jan 2022.

  9. Tobian AAR, Heddle NM, Wiegmann TL, Carso JL. Red blood cell transfusion: 2016 clinical practice guidelines from AABB. Transfusion. 2016;58(10):2627–30.

    Article  Google Scholar 

Further Reading

  • LaGamma EF. Do transfusions cause necrotizing enterocolitis? Evidence and potential mechanisms. Breastfeed Med. 2018;13(S1):S-20–2.

    Article  Google Scholar 

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Correspondence to Mark T. Friedman .

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Friedman, M.T., West, K.A., Bizargity, P., Annen, K., Gur, H.D., Hilbert, T. (2023). Tragic!. In: Immunohematology, Transfusion Medicine, Hemostasis, and Cellular Therapy. Springer, Cham. https://doi.org/10.1007/978-3-031-14638-1_78

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  • DOI: https://doi.org/10.1007/978-3-031-14638-1_78

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-14637-4

  • Online ISBN: 978-3-031-14638-1

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