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Baby Fate

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Immunohematology, Transfusion Medicine, Hemostasis, and Cellular Therapy

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Abstract

Neonatal thrombocytopenia can be problematic. Determining the cause is important to managing the newborn’s condition. Solve it!

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References

  1. Baker JM, Shehata N, Bussel J, Murphy MF, Greinacher A, Bakchoul T, et al. On behalf of the international collaboration for transfusion medicine guidelines (ICTMG). Postnatal intervention for the treatment of FNAIT: a systematic review. J Perinatol. 2019;39(10):1329–39.

    Article  PubMed  Google Scholar 

  2. Regan F, Lees CC, Jones B, Nicolaides KH, Wimalasundera RC, Mijovic A. On behalf of the Royal College of Obstetricians and Gynaecologists. Prenatal management of pregnancies at risk of fetal neonatal alloimmune thrombocytopenia (FNAIT). Scientific Impact Paper No. 61. BJOG. 2019;126:e173–85.

    Article  CAS  PubMed  Google Scholar 

  3. Epinoza JP, Caradeux J, Norwitz ER, Illanes SE. Fetal and neonatal alloimmune thrombocytopenia. Rev Obstet Gynecol. 2013;6(1):e15–21.

    Google Scholar 

  4. Peterson JA, McFarland JG, Curtis BR, Aster RH. Neonatal alloimmune thrombocytopenia: pathogenesis, diagnosis and management. Br J Haematol. 2013;161(1):3–14.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. McGuinn CE, Mitchell WB, Bussel JB. Fetal and neonatal alloimmune thrombocytopenia. In: Shaz BH, Hillyer CD, Gil MR, editiors. Transfusion Medicine and Hemostasis. 3rd ed. Netherlands: Elsevier Science; 2018. p. 581–588.

    Google Scholar 

  6. Carlsson LE, Greinacher A, Spitzer C, Walther R, Kessler C. Polymorphisms of the human platelet antigens HPA-1, HPA-2, HPA-3, and HPA-5 on the platelet receptors for fibrinogen (GPIIb/IIIa), von Willebrand factor (GPIb/IX), and collagen (GPIa/IIa) are not correlated with an increased risk for stroke. Stroke. 1997;28:1392–5.

    Article  CAS  PubMed  Google Scholar 

  7. Ohno N, Kobayashi M, Hayakawa S, Utsunomiya A, Karakawa S. Transient pseudothrombocytopenia in a neonate: transmission of a maternal EDTA-dependent anticoagulant. Platelets. 2012;23(5):399–400.

    Article  CAS  PubMed  Google Scholar 

  8. Tan GC, Stalling M, Dennis G, Nunez M, Kahwash SB. Pseudothrombocytopenia due to platelet clumping: a case report and brief review of the literature. Case Rep Hematol. 2016;2016:3036476.

    PubMed  PubMed Central  Google Scholar 

  9. Davoren A, Curtis BR, Aster RH, McFarland JG. Human platelet antigen-specific alloantibodies implicated in 1162 cases of neonatal alloimmune thrombocytopenia. Transfusion. 2004;44:1220–5.

    Article  CAS  PubMed  Google Scholar 

  10. Xu X, Chen D, Ye X, Xia W, Xu Y, Chen Y, et al. Successful prenatal therapy of anti-CD36-mediated severe FNAIT by deglycosylated antibodies in a novel murine model. Blood. 2021;138(18):1757–67.

    Article  CAS  PubMed  Google Scholar 

  11. Flesch BK, Scherer V, Opitz A, Ochmann O, Janson A, Steitz M, Zeiler T. Platelet CD36 deficiency is present in 2.6% of Arabian individuals and can cause NAIT and platelet refractoriness. Transfusion. 2021;61(6):1932–42.

    Article  CAS  PubMed  Google Scholar 

  12. Raj A, Kailsanath VP, Bertolone S, McFarland JG. Neonatal alloimmune thrombocytopenia due to HPA-9b incompatibility. Pediatr Blood Cancer. 2009;53:459–61.

    Article  PubMed  Google Scholar 

  13. Storch EK, Cushing MM. Posttransfusion purpura. In: Shaz BH, Hillyer CD, Gil MR, editors. Transfusion medicine and hemostasis. 3rd ed. Netherlands: Elsevier Science; 2018. p. 419–21.

    Google Scholar 

Further Reading

  • Baker JM, Shehata N, Bussel J, Murphy MF, Greinacher A, Bakchoul T, et al. on behalf of the International Collaboration for Transfusion Medicine Guidelines (ICTMG). Postnatal intervention for the treatment of FNAIT: a systematic review. J Perinatol. 2019;39(10):1329–39.

    Article  PubMed  Google Scholar 

  • Regan F, Lees CC, Jones B, Nicolaides KH, Wimalasundera RC, Mijovic A. On behalf of the Royal College of Obstetricians and Gynaecologists. Prenatal management of pregnancies at risk of fetal neonatal alloimmune thrombocytopenia (FNAIT). Scientific Impact Paper No. 61. BJOG. 2019;126:e173–85.

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Pathology, NYU Lagone Health, Mineola, NY, USA

    Mark T. Friedman

  2. Department of Transfusion Medicine, National Institutes of Health Clinical Center, Bethesda, MD, USA

    Kamille A. West

  3. Department of Pediatrics, Northwell Health System, Great Neck, NY, USA

    Peyman Bizargity

  4. Department of Pathology, Children’s Hospital Colorado, Aurora, CO, USA

    Kyle Annen

  5. Department of Pathology, Northwell Health System, Greenvale, NY, USA

    H. Deniz Gur

  6. Department of Pathology, NYU Langone Health, New York, NY, USA

    Timothy Hilbert

Authors
  1. Mark T. Friedman
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  2. Kamille A. West
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  3. Peyman Bizargity
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  4. Kyle Annen
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  5. H. Deniz Gur
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  6. Timothy Hilbert
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Corresponding author

Correspondence to Mark T. Friedman .

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© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG

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Friedman, M.T., West, K.A., Bizargity, P., Annen, K., Gur, H.D., Hilbert, T. (2023). Baby Fate. In: Immunohematology, Transfusion Medicine, Hemostasis, and Cellular Therapy. Springer, Cham. https://doi.org/10.1007/978-3-031-14638-1_51

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  • DOI: https://doi.org/10.1007/978-3-031-14638-1_51

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-14637-4

  • Online ISBN: 978-3-031-14638-1

  • eBook Packages: MedicineMedicine (R0)

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