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Abstract

Knowing treatment modalities to reverse novel anticoagulants can be key to saving the life of an individual who develops a bleeding complication. Solve it!

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References

  1. Gehrie E, Tormey C. Novel oral anticoagulants. Efficacy, laboratory measurement, and approaches to emergent reversal. Arch Pathol Lab Med. 2015;139:687–92.

    Article  CAS  PubMed  Google Scholar 

  2. Ikeda K, Tachibana H. Clinical implication of monitoring rivaroxaban and apixaban by using anti-factor Xa assay in patients with non-valvular atrial fibrillation. J Arrhythm. 2016;32(1):42–50.

    Article  PubMed  Google Scholar 

  3. Maier CL, Asbury WH, Duncan A, Robbins A, Ingle A, Webb A, Stowell SR, Roback JD. Using an old test for new tricks: measuring direct oral anti-Xa drug levels by conventional heparin-calibrated anti-Xa assay. Am J Hematol. 2019;94(5):E132–4.

    Article  PubMed  PubMed Central  Google Scholar 

  4. ANDEXXA®. Prescribing information. South San Francisco, CA: Portola Pharmaceuticals; 2020.

    Google Scholar 

  5. Momin JH, Hughes GJ. Andexanet alfa (Andexxa®) for the reversal of direct oral anticoagulants. P &T. 2019;44(9):530–49.

    Google Scholar 

  6. Hu TY, Vaidya VR, Asirvatham SJ. Reversing anticoagulant effects of novel oral anticoagulants: role of ciraparantag, andexanet alfa, and idarucizumab. Vasc Health Risk Manag. 2016;12:35–44.

    CAS  PubMed  PubMed Central  Google Scholar 

  7. XARELTO®. Prescribing information. Titusville, NJ: Janssen Pharmaceuticals; 2020.

    Google Scholar 

  8. ELIQUIS®. Prescribing information. Princeton, NJ: Bristol-Meyers Squibb; 2019.

    Google Scholar 

  9. BEVYXXA®. Prescribing information. South San Francisco, CA: Portola Pharmaceuticals; 2019.

    Google Scholar 

  10. SAVAYSA®. Prescribing information. Basking Ridge, NJ: Daiicho Sankyo; 2020.

    Google Scholar 

  11. Kcentra®. Prescribing information. Kankakee, IL: CSL Behring, LLC; 2018.

    Google Scholar 

  12. Galassi A, Podda G, Monciino P, Stucchi A, Del Nero A, Cozzolino M. Dabigatran overload in acute kidney injury: haemodialysis or idarucizumab? a case report and proposal for a decisional algorithm. Clin Kidney J. 2020;14(2):712–4.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Milling TJ, Kaatz S. Preclinical and clinical data for factor Xa and “universal” reversal agents. Am J Emerg Med. 2016;34(11 Suppl):39–45.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Ansell J, Laulicht B, Bakhru SH, Burnett A, Jiang X, Chen L, et al. Ciraparantag, an anticoagulant reversal drug: mechanism of action, pharmacokinetics and reversal of anticoagulants. Blood. 2021;137(1):115–25.

    Article  CAS  PubMed  Google Scholar 

  15. Beulens JW, Booth SL, van den Heuvel EG, Stoecklin E, Baka A, Vermeer C. The role of menaquinones (vitamin K2) in human health. Br J Nutr. 2013;110(8):1357–68.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Mark T. Friedman .

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Friedman, M.T., West, K.A., Bizargity, P., Annen, K., Gur, H.D., Hilbert, T. (2023). Head Shot!. In: Immunohematology, Transfusion Medicine, Hemostasis, and Cellular Therapy. Springer, Cham. https://doi.org/10.1007/978-3-031-14638-1_37

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  • DOI: https://doi.org/10.1007/978-3-031-14638-1_37

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-14637-4

  • Online ISBN: 978-3-031-14638-1

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