Abstract
Pulmonary Langerhans cell histiocytosis (PLCH) is a histiocytic disorder caused by abnormal proliferation of myeloid-derived dendritic cells. Other than the presence of the namesake Langerhans cells, the histopathologic findings in this disorder overlap with many inflammatory and fibrotic conditions that can affect lung tissue. Nodular lung disease with fibrosis and remodeling of alveolar parenchyma are findings common to both PLCH and the organizing pneumonia pattern of injury. Furthermore, organizing pneumonia can be seen in PLCH. This chapter aims to explore this diagnostic challenge and highlight the most useful features to avoid a missed diagnosis of PLCH when it is associated with fibrosis.
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Long, T.H., Xu, H. (2022). Pulmonary Langerhans Cell Histiocytosis with Fibrosis Versus Organizing Pneumonia. In: Xu, H., Ricciotti, R.W., Mantilla, J.G. (eds) Practical Lung Pathology. Practical Anatomic Pathology. Springer, Cham. https://doi.org/10.1007/978-3-031-14402-8_43
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DOI: https://doi.org/10.1007/978-3-031-14402-8_43
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