Abstract
Chronic eosinophilic pneumonia (CEP) and organizing pneumonia (OP) are airspace-predominant diseases with significant clinical, radiographic, and histologic overlap. CEP can sometimes have foci of OP, and separation of the two entities can be further complicated after corticosteroid treatment, when eosinophils are rapidly depleted. This chapter defines and provides key diagnostic differences between these two entities. CEP presents at a more peripheral location on imaging and is often associated with peripheral eosinophilia, while cryptogenic OP does not. Histopathological clues toward a diagnosis of CEP include location of eosinophilic infiltrates and their abundance compared to airspace-filling fibroblastic plugs observed in OP. Although treatment for both entities is similar in the use of corticosteroids, CEP has a significantly higher relapse rate. Additionally, OP may benefit from further investigation and treatment of its etiology, whereas CEP is viewed as an idiopathic diagnosis of exclusion.
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Han, L., Xu, H. (2022). Chronic Eosinophilic Pneumonia Versus Organizing Pneumonia. In: Xu, H., Ricciotti, R.W., Mantilla, J.G. (eds) Practical Lung Pathology. Practical Anatomic Pathology. Springer, Cham. https://doi.org/10.1007/978-3-031-14402-8_42
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DOI: https://doi.org/10.1007/978-3-031-14402-8_42
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