Abstract
Organizing pneumonia (OP) and usual interstitial pneumonia (UIP) are two histopathologic patterns of interstitial lung disease and are each associated with different clinical presentations. Recognition of either pattern is important, especially because UIP is the typical histopathologic pattern of idiopathic pulmonary fibrosis (IPF), which has significant prognostic and treatment implications. OP and UIP have histologic features that can be conflated at first glance, namely, the so-called Masson bodies of OP and the often-seen “fibroblastic foci” of UIP pattern. Careful examination of the pattern and distribution of fibrosis and findings of honeycomb change are helpful in establishing a pathologic diagnosis of UIP. Clinical and radiologic correlations are also important in forming an accurate differential diagnosis. OP is nonspecific and can be seen in a variety of diseases (including acute exacerbations of UIP). The diagnosis of cryptogenic organizing pneumonia (COP) can only be made in the absence of other findings and etiologies for lung disease.
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Mau, B., Johnson, L.N., Xu, H. (2022). Organizing Pneumonia Versus Usual Interstitial Pneumonia. In: Xu, H., Ricciotti, R.W., Mantilla, J.G. (eds) Practical Lung Pathology. Practical Anatomic Pathology. Springer, Cham. https://doi.org/10.1007/978-3-031-14402-8_40
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DOI: https://doi.org/10.1007/978-3-031-14402-8_40
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