Abstract
Proteinuric kidney diseases such as focal segmental glomerulosclerosis (FSGS) can recur after kidney transplantation. This case reviews the presentation and course of a patient with “minimal change disease” who had recurrence early after transplant. We later describe the patient’s development of rejection, highlighting the need for ongoing vigilance with respect to suspicion of rejection in patients with recurrent native kidney disease. We discuss various treatments and long-term outcomes of patients with recurrent FSGS.
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References
Hariharan S, Adams MB, Brennan DC, et al. Recurrent and de novo glomerular disease after renal transplantation: a report from renal allograft disease registry (RADR). Transplantation. 1999;68(5):635–41.
Canaud G, Audard V, Kofman T, Lang P, Legendre C, Grimbert P. Recurrence from primary and secondary glomerulopathy after renal transplant. Transpl Int. 2012;25(8):812–24.
Gohh RY, Yango AF, Morrissey PE, et al. Preemptive plasmapheresis and recurrence of FSGS in high-risk renal transplant recipients. American journal of transplantation. 2005;5(12):2907–12.
Francis A, Trnka P, McTaggart SJ. Long-term outcome of kidney transplantation in recipients with focal segmental glomerulosclerosis. CJASN. 2016;11(11):2041–6.
Uffing A, Pérez-Sáez MJ, Mazzali M, et al. Recurrence of FSGS after kidney transplantation in adults. Clin J Am Soc Nephrol. 2020;15(2):247–56.
Chang JW, Pardo V, Sageshima J, et al. Podocyte foot process effacement in postreperfusion allograft biopsies correlates with early recurrence of proteinuria in focal segmental glomerulosclerosis. Transplantation. 2012;93(12):1238–44.
Gallon L, Leventhal J, Skaro A, Kanwar Y, Alvarado A. Resolution of recurrent focal segmental glomerulosclerosis after Retransplantation. N Engl J Med. 2012;366(17):1648–9.
Garrouste C, Canaud G, Büchler M, et al. Rituximab for recurrence of primary focal segmental glomerulosclerosis after kidney transplantation: clinical outcomes. Transplantation. 2017;101(3):649–56.
Alhamad T, Manllo Dieck J, Younus U, et al. ACTH gel in resistant focal segmental glomerulosclerosis after kidney transplantation. Transplantation. 2019;103(1):202–9.
Grafals M, Sharfuddin A. Adrenocorticotropic hormone in the treatment of focal segmental glomerulosclerosis following kidney transplantation. Transplant Proc. 2019;51(6):1831–7.
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Santos, R.D., Alhamad, T. (2022). Recurrent Heavy Proteinuria and Focal Segmental Glomerulosclerosis Post-Kidney Transplant. In: Aziz, F., Parajuli, S. (eds) Complications in Kidney Transplantation. Springer, Cham. https://doi.org/10.1007/978-3-031-13569-9_45
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DOI: https://doi.org/10.1007/978-3-031-13569-9_45
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