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Abnormal Glycosylation in Cancer Cells and Cancer Stem Cells as a Therapeutic Target

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Cancer Stem Cell Markers and Related Network Pathways

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1393))

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Abstract

Tumor resistance and recurrence have been associated with the presence of cancer stem cells (CSCs) in tumors. The functions and survival of the CSCs have been associated with several intracellular and extracellular features. Particularly, the abnormal glycosylation of these signaling pathways and markers of CSCs have been correlated with maintaining survival, self-renewal and extravasation properties. Here, we highlight the importance of glycosylation in promoting the stemness character of CSCs and the current strategies for targeting abnormal glycosylation toward generating effective therapies against the CSC population.

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Quader, S., Tanabe, S., Cabral, H. (2022). Abnormal Glycosylation in Cancer Cells and Cancer Stem Cells as a Therapeutic Target. In: Tanabe, S. (eds) Cancer Stem Cell Markers and Related Network Pathways. Advances in Experimental Medicine and Biology, vol 1393. Springer, Cham. https://doi.org/10.1007/978-3-031-12974-2_7

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