Skip to main content

Vaccination

  • Chapter
  • First Online:
Absolute Allergy and Immunology Board Review

Abstract

The importance of global vaccines for various infectious agents has been emphasized through our experience with the current COVID-19 vaccine. Physicians trained in allergy and immunology are considered experts in vaccines and adverse reactions from vaccines. This chapter will emphasize how to approach vaccines for various populations, including immunodeficient patients, how to determine best paths for patients who miss vaccine doses, and how to address adverse reactions to vaccines, as noted in Case 2, where the patient experienced an anaphylactic reaction to the measles, mumps, and rubella (MMR) vaccine. In addition, mechanisms behind adverse vaccine reactions are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 119.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 159.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Bibliography

  1. Kounis NG, Koniari I, de Gregorio C, Velissaris D, Petalas K, Brinia A, et al. Allergic reactions to current available covid-19 vaccinations: pathophysiology, causality, and therapeutic considerations. Vaccines. 2021;9:221.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Banerji A, Wickner PG, Saff R, Stone CA, Robinson LB, Long AA, et al. mRNA vaccines to prevent COVID-19 disease and reported allergic reactions: current evidence and suggested approach. J Allergy Clin Immunol Pract. 2021;9:1423–37.

    Article  CAS  PubMed  Google Scholar 

  3. Albrecht M, Arck PC. Vertically transferred immunity in neonates: mothers. Mechanisms and mediators. Front Immunol. 2020;11:555.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Cunningham-Rundles C. How I treat common variable immune deficiency. Blood. 2010;116:7–15.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Rubin LG, Levin MJ, Per Ljungman E, Davies G, Avery R, Tomblyn M, et al. 2013 IDSA clinical practice guideline for vaccination of the immunocompromised host. Clin Infect Dis. 2014;58:309–18.

    Article  PubMed  Google Scholar 

  6. Sobh A, Bonilla FA. Vaccination in primary immunodeficiency disorders. J Allergy Clin Immunol Pract. 2016;4:1066–75.

    Article  PubMed  Google Scholar 

  7. McNeil MM, Weintraub ES, Duffy J, Sukumaran L, Jacobsen SJ, Klein NP, et al. Risk of anaphylaxis after vaccination in children and adults. J Allergy Clin Immunol. 2016;137:868–78.

    Article  PubMed  Google Scholar 

  8. Sakaguchi M, Nakayama T, Inouye S. Food allergy to gelatin in children with systemic immediate-type reactions, including anaphylaxis, to vaccines. J Allergy Clin Immunol. 1996;98:1058–61.

    Article  CAS  PubMed  Google Scholar 

  9. Kelso JM, Jones RT, Yunginger JW. Anaphylaxis to measles, mumps, and rubella vaccine mediated by IgE to gelatin. J Allergy Clin Immunol. 1993;91:867–72.

    Article  CAS  PubMed  Google Scholar 

  10. Kelso JM, Greenhawt MJ, Li JT, Nicklas RA, Bernstein DI, Blessing-Moore J, et al. Adverse reactions to vaccines practice parameter 2012 update. J Allergy Clin Immunol. 2012;130:25–43.

    Article  PubMed  Google Scholar 

  11. Banerji A, Wolfson AR, Wickner PG, Cogan AS, McMahon AE, Saff R, et al. COVID-19 vaccination in patients with reported allergic reactions: updated evidence and suggested approach. J Allergy Clin Immunol Pract. 2021;9:2135–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Shimabukuro TT, Cole M, Su JR. Reports of anaphylaxis after receipt of mRNA COVID-19 vaccines in the US-December 14, 2020-January 18, 2021. JAMA—J Am Med Assoc. 2021;325:1101–2. https://doi.org/10.1001/jama.2021.1967

  13. Blumenthal KG, Freeman EE, Saff RR, Robinson LB, Wolfson AR, Foreman RK, et al. Delayed large local reactions to mRNA-1273 vaccine against SARS-CoV-2. N Engl J Med. 2021;384:1273–7.

    Article  PubMed  Google Scholar 

  14. McMahon DE, Amerson E, Rosenbach M, Lipoff JB, Moustafa D, Tyagi A, et al. Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: a registry-based study of 414 cases. J Am Acad Dermatol. 2021;85:46–55.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Furer V, Zisman D, Kibari A, Rimar D, Paran Y, Elkayam O. Herpes zoster following BNT162b2 mRNA Covid-19 vaccination in patients with autoimmune inflammatory rheumatic diseases: a case series. Rheumatology. 2021;60:SI90–5.

    Article  CAS  PubMed  Google Scholar 

  16. Chung EH. Vaccine allergies. Clin Exp. Vaccine Res. 2014;3:50–7.

    CAS  Google Scholar 

  17. Kazatchkine MD, Kaveri SV. Immunomodulation of autoimmune and inflammatory diseases with intravenous immune globulin. N Engl J Med. 2001;345:747–55.

    Article  CAS  PubMed  Google Scholar 

  18. Hamborsky J, Kroger A, Wolfe SE, Centers for Disease Control and Prevention. Epidemiology and prevention of vaccine-preventable diseases. Atlanta, GA: Centers for Disease Control and Prevention; 2015.

    Google Scholar 

  19. Dreskin SC, Halsey NA, Kelso JM, Wood RA, Hummell DS, Edwards KM, et al. International Consensus (ICON): allergic reactions to vaccines. World Allergy Organ J. 2016;9:32.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Furer V, Zisman D, Kibari A, Rimar D, Paran Y, Elkayam O. Herpes zoster following BNT162b2 mRNA Covid-19 vaccination in patients with autoimmune inflammatory rheumatic diseases: a case series. Rheumatology. 2021. https://doi.org/10.1093/rheumatology/keab345

  21. Greenhawt M, Turner PJ, Kelso JM. Administration of influenza vaccines to egg allergic recipients: A practice parameter update 2017. Ann Allergy, Asthma Immunol. 2018. https://doi.org/10.1016/j.anai.2017.10.020

  22. Stone CA, Rukasin CRF, Beachkofsky TM, Phillips EJ. Immune-mediated adverse reactions to vaccines. Br J Clin Pharmacol. 2019. https://doi.org/10.1111/bcp.14112

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Joseph Yusin .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2022 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Jaspreet, D., Vivian, W., Ziwei, W., Brittney, P., Jamie, Y., Yusin, J. (2022). Vaccination. In: Mahmoudi, M. (eds) Absolute Allergy and Immunology Board Review. Springer, Cham. https://doi.org/10.1007/978-3-031-12867-7_30

Download citation

  • DOI: https://doi.org/10.1007/978-3-031-12867-7_30

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-12866-0

  • Online ISBN: 978-3-031-12867-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics