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Nanoarchaeosomes in Drug Delivery

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Pharmaceutical Nanobiotechnology for Targeted Therapy

Part of the book series: Nanotechnology in the Life Sciences ((NALIS))

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Abstract

Nanoarchaeosomes are roughly smaller than 600-nm-diameter vesicles, having a mono- or oligolamellar monolayer or a bilayer membrane, made of pure archaeolipids, or in combination with other amphipathic molecules. They share morphology with liposomes but exhibit different properties, from their lipid stereoisomerism, their reactivity in front to chemical and physical agents, to their membrane fluidity and permeability, besides their heterogeneous compositions, considerably wider than those of liposomes. Such differences make them attractive as biomaterials constituting new lipid-based nanomedicines offering high structural stability and simple preparation at a lab and industrial scale, two disadvantages of a eukaryote or bacterial lipids-based nanomedicines. This chapter offers first a snapshot of archaea, since each gender, according to its habitat and metabolism, produces a given type or archaeolipid that will be responsible for the specific characteristics of each type or nanoarchaeosome. This is followed by an updated revision on the preclinical applications of nanoarchaeosomes in drug delivery.

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Authors and Affiliations

  1. Nanomedicines Research and Development Centre (NARD), Science and Technology Department, National University of Quilmes, Bernal, Buenos Aires, Argentina

    Eder Lilia Romero & Maria Jose Morilla

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  1. Eder Lilia Romero
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  2. Maria Jose Morilla
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Correspondence to Eder Lilia Romero .

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  1. Department of Pharmaceutical Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Science, Tehran, Iran

    Hamed Barabadi

  2. Stanford Cardiovascular Institute & Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA

    Ebrahim Mostafavi

  3. AMR and Nanotherapeutics Laboratory, Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, India

    Muthupandian Saravanan

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Romero, E.L., Morilla, M.J. (2022). Nanoarchaeosomes in Drug Delivery. In: Barabadi, H., Mostafavi, E., Saravanan, M. (eds) Pharmaceutical Nanobiotechnology for Targeted Therapy. Nanotechnology in the Life Sciences. Springer, Cham. https://doi.org/10.1007/978-3-031-12658-1_6

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