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Neovascular Glaucoma in Ocular Ischemic Syndrome

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Neovascular Glaucoma

Part of the book series: Essentials in Ophthalmology ((ESSENTIALS))

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Abstract

Ocular ischemic syndrome (OIS) is an uncommon and underdiagnosed etiology of neovascular glaucoma (NVG). Its underlying pathophysiology may vary, but at its core is due to decreased perfusion of the eye. Classically, OIS is associated with stenosis of the ipsilateral carotid artery. Clinically, it may present with subacute decreased vision, amaurosis, ocular angina and an array of anterior and posterior findings including neovascularization (of the iris, angle, nerve, and/or retina), anterior chamber inflammation, and mid-peripheral retinal hemorrhages. Management is multidisciplinary and crosses subspecialties. This may involve retinal specialists for definitive diagnosis and additional therapeutic procedures as well as referral to other medical and surgical specialties for management of vascular risk factors and surgical revascularization. NVG may or may not be present in patients with OIS. Therapy specifically for NVG secondary to OIS has not been extensively studied and requires further research.

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References

  1. Brown GC, Sharma S. Ocular ischemic syndrome. Retina. 2013:1091–103.

    Google Scholar 

  2. Mendrinos E, Machinis TG, Pournaras CJ. Ocular ischemic syndrome. Surv Ophthalmol. 2010;55:2–34.

    Article  Google Scholar 

  3. Anguita R, Nazar C, Kobus R, Salinas A, Astete M. Bilateral ocular ischemic syndrome as a manifestation of Takayasu arteritis in children. Can J Ophthalmol. 2019;54:e105–8.

    Article  Google Scholar 

  4. Papavasileiou E, Sobrin L, Papaliodis GN. Ocular ischemic syndrome presenting as retinal vasculitis in a patient with moyamoya syndrome. Retin Cases Brief Rep. 2015;9:170–2.

    Article  Google Scholar 

  5. Brown GC, Magargal LE. The ocular ischemic syndrome: clinical, fluorescein angiographic and carotid angiographic features. Int Ophthalmol. 1988;11:239–51.

    Article  CAS  Google Scholar 

  6. Kearns TP. Ophthalmology and the carotid artery. Am J Ophthalmol. 1979;88:714–22.

    Article  CAS  Google Scholar 

  7. Kobayashi S, Hollenhorst RW, Sundt TM Jr. Retinal arterial pressure before and after surgery for carotid artery stenosis. Stroke. 1971;2:569–75.

    Article  CAS  Google Scholar 

  8. Sturrock GD, Mueller HR. Chronic ocular ischaemia. Br J Ophthalmol. 1984;68:716–23.

    Article  CAS  Google Scholar 

  9. Brown GC, Magargal LE, Schachat A, Shah H. Neovascular glaucoma. Etiologic considerations. Ophthalmology. 1984;91:315–20.

    Article  CAS  Google Scholar 

  10. Sivalingam A, Brown GC, Magargal LE. The ocular ischemic syndrome. III. Visual prognosis and the effect of treatment. Int Ophthalmol. 1991;15:15–20.

    Article  CAS  Google Scholar 

  11. Winterkorn JM, Teman AJ. Recurrent attacks of amaurosis fugax treated with calcium channel blocker. Ann Neurol. 1991;30:423–5.

    Article  CAS  Google Scholar 

  12. Aasen J, Kerty E, Russell D, Bakke SJ, Nyberg-Hansen R. Amaurosis fugax: clinical, Doppler and angiographic findings. Acta Neurol Scand. 1988;77:450–5.

    Article  CAS  Google Scholar 

  13. Mizener JB, Podhajsky P, Hayreh SS. Ocular ischemic syndrome. Ophthalmology. 1997;104:859–64.

    Article  CAS  Google Scholar 

  14. Countee RW, Gnanadev A, Chavis P. Dilated episcleral arteries--a significant physical finding in assessment of patients with cerebrovascular insufficiency. Stroke. 1978;9:42–5.

    Article  CAS  Google Scholar 

  15. Duker JS, Brown GC, Bosley TM, Colt CA, Reber R. Asymmetric proliferative diabetic retinopathy and carotid artery disease. Ophthalmology. 1990;97:869–74.

    Article  CAS  Google Scholar 

  16. Sivalingam A, Brown GC, Magargal LE, Menduke H. The ocular ischemic syndrome. II. Mortality and systemic morbidity. Int Ophthalmol. 1989;13:187–91.

    Article  CAS  Google Scholar 

  17. Cohn EJ Jr, Sandager GP, Benjamin ME, Lilly MP, Hanna DJ, Flinn WR. Assessment of ocular perfusion after carotid endarterectomy with color-flow duplex scanning. J Vasc Surg. 1999;29:665–71.

    Article  Google Scholar 

  18. Geroulakos G, Botchway LT, Pai V, Wilkinson AR, Galloway JM. Effect of carotid endarterectomy on the ocular circulation and on ocular symptoms unrelated to emboli. Eur J Vasc Endovasc Surg. 1996;11:359–63.

    Article  CAS  Google Scholar 

  19. Lauria AL, Koelling EE, Houghtaling PM, White PW (2020) Carotid endarterectomy for ocular ischemic syndrome: a case report and review of the literature. Ann Vasc Surg.

    Google Scholar 

  20. American Symptomatic Carotid N. Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. N Engl J Med. 1991;325:445–53.

    Article  Google Scholar 

  21. Kawano T, Saito K, Hidaka T, Kajihara N, Chuman H, Ohta H, Yokogami K, Takeshima H. Two patients with a rapid increase in the ocular pressure after carotid artery stenting for cervical internal carotid artery stenosis with ocular ischemic syndrome. J Neuroendovascular Therapy. 2018;12:553–9.

    Article  Google Scholar 

  22. Ng E, Choong AM, Walker PJ. Neovascular glaucoma post carotid endarterectomy: a case report and review of the literature. Ann Vasc Dis. 2015;8:103–5.

    Article  Google Scholar 

  23. EC/IC Bypass Study Group. Failure of extracranial-intracranial arterial bypass to reduce the risk of ischemic stroke. Results of an international randomized trial. N Engl J Med. 1985;313:1191–200.

    Article  Google Scholar 

  24. Kiser WD, Gonder J, Magargal LE, Sanborn GE, Simeone F. Recovery of vision following treatment of the ocular ischemic syndrome. Ann Ophthalmol. 1983;15:305–10.

    CAS  Google Scholar 

  25. Higgins RA. Neovascular glaucoma associated with ocular hypoperfusion secondary to carotid artery disease. Aust J Ophthalmol. 1984;12:155–62.

    Article  CAS  Google Scholar 

  26. Kawaguchi S, Iida J-I, Hashimoto H, Sakaki T. The role of STA-MCA bypass for the ocular ischemic syndrome due to the occlusive internal carotid artery diseases. Surg Cerebral Stroke. 2003;13:419–23.

    Article  Google Scholar 

  27. Coppeto JR, Wand M, Bear L, Sciarra R. Neovascular glaucoma and carotid artery obstructive disease. Am J Ophthalmol. 1985;99:567–70.

    Article  CAS  Google Scholar 

  28. Hayreh SS, Baines JA. Occlusion of the vortex veins. An experimental study. Br J Ophthalmol. 1973;57:217–38.

    Article  CAS  Google Scholar 

  29. Malhotra R, Gregory-Evans K. Management of ocular ischaemic syndrome. Br J Ophthalmol. 2000;84:1428–31.

    Article  CAS  Google Scholar 

  30. Amselem L, Montero J, Diaz-Llopis M, Pulido JS, Bakri SJ, Palomares P, Garcia-Delpech S. Intravitreal bevacizumab (Avastin) injection in ocular ischemic syndrome. Am J Ophthalmol. 2007;144:122–4.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Ophthalmology and Visual Science, The University of Chicago Medicine and Biological Sciences, Chicago, IL, USA

    Zhuangjun Si & Seenu M. Hariprasad

  2. Duke Ophthalmology, Duke University School of Medicine, Durham, NC, USA

    Zhuangjun Si

Authors
  1. Zhuangjun Si
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  2. Seenu M. Hariprasad
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Correspondence to Seenu M. Hariprasad .

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Editors and Affiliations

  1. Ophthalmology and Visual Science, University of Chicago, Chicago, IL, USA

    Mary Qiu

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Si, Z., Hariprasad, S.M. (2022). Neovascular Glaucoma in Ocular Ischemic Syndrome. In: Qiu, M. (eds) Neovascular Glaucoma. Essentials in Ophthalmology. Springer, Cham. https://doi.org/10.1007/978-3-031-11720-6_8

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  • DOI: https://doi.org/10.1007/978-3-031-11720-6_8

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-11719-0

  • Online ISBN: 978-3-031-11720-6

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