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Neovascular Glaucoma in Chronic Retinal Detachments

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Neovascular Glaucoma

Part of the book series: Essentials in Ophthalmology ((ESSENTIALS))

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Abstract

Development, persistence, and treatment of rhegmatogenous retinal detachments (RRD) can all predispose to the development of neovascular glaucoma (NVG). Retinal breaks result in the breakdown of the uveo-vascular barrier, triggering a pro-inflammatory response, retinal ischemia and injury, and ultimately overexpression of vascular endothelial growth factor (VEGF) and other pro-angiogenic factors. These changes may be reversed to some extent with timely retinal detachment repair, although a non-negligible number of retinal detachments worldwide remain unrepaired, are repaired late, or are never diagnosed. Scleral buckling, vitrectomy, retinectomy, and lensectomy to repair retinal detachment may themselves predispose eyes to NVG by inducing ischemia (scleral buckle, retinectomy) or enabling more rapid diffusion of pro-angiogenic factors to the anterior segment (vitrectomy, lensectomy). Anti-VEGF offers a temporary alternative to surgery in patients who are high-risk surgical candidates; however, no established protocol exists for this indication.

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  1. Aaron Priluck and Loka Thangamathesvaran contributed equally with all other contributors.

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  1. Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Aaron Priluck, Loka Thangamathesvaran & Ravi Pandit

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  1. Aaron Priluck
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  1. Ophthalmology and Visual Science, University of Chicago, Chicago, IL, USA

    Mary Qiu

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Priluck, A., Thangamathesvaran, L., Pandit, R. (2022). Neovascular Glaucoma in Chronic Retinal Detachments. In: Qiu, M. (eds) Neovascular Glaucoma. Essentials in Ophthalmology. Springer, Cham. https://doi.org/10.1007/978-3-031-11720-6_10

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  • DOI: https://doi.org/10.1007/978-3-031-11720-6_10

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