Abstract
Upon prolonged immunogenic stimulation, an antigen-specific adaptive defense response is initiated. The established signaling of the innate defense phase is transferred to the adaptive phase of the defense response by the immune cells involved through PRRs and CRs. Various food-associated carbohydrate and peptide structures, fatty acids as well as bacteria and yeasts can already indirectly influence adaptive immune responses. Food is essential for the development and maintenance of these immune functions, but it can also cause pathological–immunological hyperreactions.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Further Reading
Borghini R, Di Tola M, Salvi E, Isonne C, Puzzono M, Marino M, Picarelli A (2016) Impact of gluten-free diet on quality of life in celiac patients. Act Gastro Enterol Belg 79(2):447–453
Cenit MC, Olivares M, Codoñer-Franch P, Sanz Y (2015) Intestinal microbiota and celiac disease: cause, consequence or co-evolution? Nutrients 7(8):6900–6923. https://doi.org/10.3390/nu7085314
Diller ML, Kudchadkar RR, Delman KA, Lawson DH, Ford ML (2016) Balancing inflammation: the link between th17 and regulatory t cells. Mediators Inflamm. https://doi.org/10.1155/2016/6309219
Dustin ML, Choudhuri K (2016) Signaling and polarized communication across the T cell immunological synapse. Ann Rev Cell Dev Biol 32:303–325. https://doi.org/10.1146/annurev-cellbio-100814-125330
Faria AM, Gomes-Santos AC, Gonçalves JL, Moreira TG, Medeiros SR, LPA2 D, DC2 C (2013) Food components and the immune system: from tonic agents to allergens. Front Immunol Mucosal Immunity 4(102). https://doi.org/10.3389/fimmu.2013.00102
Fußbroich D, Schubert R, Schneider P, Zielen S, Beermann C (2015) Impact of soyasaponin I on TLR2 and TLR4 induced inflammation in the MUTZ-3-cell model. Food Funct 6:1001–1010. https://doi.org/10.1039/C4FO01065E
Girbovan A, Sur G, Samasca G, Lupan I (2017) Dysbiosis a risk factor for celiac disease. Med Microbiol Immunol 206(2):83–91. https://doi.org/10.1007/s00430-017-0496-z
Gobbetti M, Pontonio E, Filannino P, Rizzello CG, Angelis M, Di Cagno R (2017) How to improve the gluten-free diet. The state of the art from a food science perspective. Food Res Int. https://doi.org/10.1016/j.foodres.2017.04.010
Harald Renz H, Allen KJ, Sicherer SH, Lack G, Beyer K, Oettgen H (2018) Food allergy. Nat Rev Dis Primers 4. https://doi.org/10.1038/nrdp.2017.98
Kaukinen K, Lindfors K (2015) Novel treatments for celiac disease. Glutenases and beyond. Dig Dis 33(2):277–281. https://doi.org/10.1159/000369536
Kidd P (2003) Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease. Altern Med Rev 8(3):223–246
Kumar J, Kumar M, Pandey R, Chauhan NS (2017) Physiopathology and management of gluten-induced celiac disease. J Food Sci 82(2):270–277. https://doi.org/10.1111/1750-3841.13612
Martinello F, Roman CF, Souza P (2017) Effects of probiotic intake on intestinal bifidobacteria of celiac patients. Arq Gastroenterol 54(2):85–90. https://doi.org/10.1590/S0004-2803.201700000-07
Netea MG, Van der Meer JWM, Sutmuller RP, Adema GJ, Kullberg B-J (2005) From the Th1/Th2 paradigm toward a toll-like receptor/T-helper bias. Antimicrob Agent Chemother 49(10):3991–3996
Pinto-Sánchez MI, Causada-Calo N, Bercik P, Ford AC, Murray JA, Armstrong D, Semrad C, Kupfer SS, Alaedini A, Moayyedi P, Leffler DA, Verdú EF, Green P (2017) Safety of adding oats to a gluten-free diet for patients with celiac disease. Systematic review and meta-analysis of clinical and observational studies. Gastroenterology 153(2):395–409. https://doi.org/10.1053/j.gastro.2017.04.009
Ruggiero F, Angelis M, Rizzello CG, Noemi C, Dal BF, Gobbetti M (2017) Selected probiotic lactobacilli have the capacity to hydrolyze gluten peptides during simulated gastrointestinal digestion. Appl Environ Microbiol 83(14). https://doi.org/10.1128/AEM.00376-17
Saeidnia S, Manayi A, Abdollahi M (2015) From in vitro experiments to in vivo and clinical studies; pros and cons. Curr Drug Discov Technol 12(4):218–224
Sicherer SH, Sampson HA (2018) Food allergy: a review and update on epidemiology, pathogenesis, diagnosis, prevention, and management. J Allergy Clin Immunol 141(1):41–58. https://doi.org/10.1016/j.jaci.2017.11.003
Tao L, Reese TA (2017) Making mouse models that reflect human immune responses. Trends Immunol 38(3):181–193. https://doi.org/10.1016/j.it.2016.12.007
Van Neerven R, Savelkoul H (2017) Nutrition and allergic diseases. Nutrients 9(7):762. https://doi.org/10.3390/nu9070762
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this chapter
Cite this chapter
Beermann, C. (2023). The Adaptive Defense Response: Physiological and Pathological Stimulatory Potential of Food Components in the Antigen-Specific Immune Response. In: Food and the Immune System. Springer, Cham. https://doi.org/10.1007/978-3-031-11523-3_4
Download citation
DOI: https://doi.org/10.1007/978-3-031-11523-3_4
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-031-11522-6
Online ISBN: 978-3-031-11523-3
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)