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Deep Learning-Based Longitudinal Intra-subject Registration of Pediatric Brain MR Images

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Part of the Lecture Notes in Computer Science book series (LNCS,volume 13386)


Deep learning (DL) techniques have the potential of allowing fast deformable registration tasks. Studies around registration often focus on adult populations, while there is a need for pediatric research where less data and studies are being produced. In this work, we investigate the potential of unsupervised DL-based registration in the context of longitudinal intra-subject registration on 434 pairs of publicly available Calgary Preschool dataset of children aged 2–7 years. This deformable registration task was implemented using the DeepReg toolkit. It was tested in terms of input spatial image resolution (1.5 vs 2.0 mm isotropic) and three pre-alignement strategies: without (NR), with rigid (RR) and with rigid-affine (RAR) initializations. The evaluation compares regions of overlap between warped and original tissue segmentations using the Dice score. As expected, RAR with an input spatial resolution of 1.5 mm shows the best performances. Indeed, RAR has an average Dice score of of 0.937 ± 0.034 for white matter (WM) and 0.959 ± 0.020 for gray matter (GM) as well as showing small median percentages of negative Jacobian determinant (JD) values. Hence, this shows promising performances in the pediatric context including potential neurodevelopmental studies.


  • Learning-based image registration
  • Pediatric
  • MRI

Supported by Polytechnique Montréal, by the Canada First Research Excellence Fund, and by the TransMedTech Institute.

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Correspondence to Andjela Dimitrijevic , Vincent Noblet or Benjamin De Leener .

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Dimitrijevic, A., Noblet, V., De Leener, B. (2022). Deep Learning-Based Longitudinal Intra-subject Registration of Pediatric Brain MR Images. In: Hering, A., Schnabel, J., Zhang, M., Ferrante, E., Heinrich, M., Rueckert, D. (eds) Biomedical Image Registration. WBIR 2022. Lecture Notes in Computer Science, vol 13386. Springer, Cham.

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-11202-7

  • Online ISBN: 978-3-031-11203-4

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