Abstract
Nutritional rickets is a multisystemic disease that occurs in the setting of Vitamin D deficiency and decreased serum calcium. Diagnostic criteria include clinical, radiographic, and laboratory findings. Nutritional rickets presents with a variety of manifestations, including alterations of the skeletal system. Orthopedic providers have the opportunity to recognize clinical findings suggestive of nutritional rickets with a focused physical exam, complemented by imaging studies. Awareness of high-risk populations may expedite early identification and appropriate treatment of affected children. Knowledge of standardized recommendations regarding Vitamin D and calcium intake may prevent rickets and facilitate treatment with supplementation.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Folson L, DiMeglio L. Recommendations released on prevention, management of rickets. AAP News. Epub 2017 Feb 10. http://www.aappublications.org/news/2017/02/10/Rickets021017.
Gonzalez Ballesteros LF, Ma N, Ward L, Backeljauw P, Wasserman H, Weber D, DiMeglio L, et al. Hypophosphatemia associated with elemental formula use in children with feeding problems. In Annual meeting of the pediatric academic societies, Baltimore, MD. May 2016. Abstract #3853.
Munn CF, Shaw N, Kiely M, Specker BL, Thacher TD, Ozono K, et al. Global consensus recommendations of prevention and management of nutritional rickets. J Clin Endocrinol Metab. 2016;101(2):394–415. Epub 2016 Jan 8.
Misra M, Pacaud D, Petryk A, Collett-Solberg PF, Kappy M. Vitamin D deficiency in children and its management: review of current knowledge and recommendations. Pediatrics. 2008;122(2):398.
Holick MF, Shao Q, Liu WW, Tai C. The Vitamin D content of fortified mild and infant formula. N Engl J Med. 1992;326:1178–81.
Thacher TD, Clarke BL. Vitamin D insufficiency. Mayo Clin Proc. 2011;86(1):50–60.
Tiosano D, Hochberg Z. Hypophosphatemia: the common denominator of all rickets. J Bone Miner Metab. 2009;27(4):392–401.
Lambert AS, Linglart A. Hypocalcaemic and hypophosphatemic rickets. Best Pract Res Clin Endocrinol Metab. 2018;32(4):455–76.
Thandrayen K, Pettifor JM. The roles of Vitamin D and dietary calcium in nutritional rickets. Bone Rep. 2018;8:81–9.
Maiya S, Sullivan I, Allgrove J, et al. Hypocalcaemia and Vitamin D deficiency: an important, but preventable, cause of life-threatening infant heart failure. Heart. 2008;94(5):581–4.
Carpenter TO. The expanding family of hypophosphatemic syndromes. J Bone Miner Metab. 2012;30(1):1–9.
POLYOSTOTIC FIBROUS DYSPLASIA, INCLUDED; PFD, INCLUDED; POFD, INCLUDED. Johns Hopkins University. Online Mendelian Inheritance in Man (OMIM) Web site. Accessed 16 Oct 2019.
Acar S, Demir K, Shi Y. Genetic causes of rickets. J Clin Res Pediatr Endocrinol. 2017;9(Suppl 2):88–105.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2023 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Zolkoske, A.C. (2023). Nutritional and Genetic Rickets. In: Sarwark, J.F., Carl, R.L. (eds) Orthopaedics for the Newborn and Young Child. Springer, Cham. https://doi.org/10.1007/978-3-031-11136-5_37
Download citation
DOI: https://doi.org/10.1007/978-3-031-11136-5_37
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-031-11135-8
Online ISBN: 978-3-031-11136-5
eBook Packages: MedicineMedicine (R0)