Abstract
In the previous chapter, we described the renal vasoactive hormones and their contribution to kidney excretory function and blood pressure regulation. This chapter addresses the pathophysiological alterations of these vasoactive hormonal systems and their contribution to chronic kidney disease and salt-sensitive high blood pressure.
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Bibliography
Buffin-Meyer B, Younes-Ibrahim M, El Mernissi G, Cheval L, Marsy S, Grima M, Girolami JP, Doucet A (2004) Differential regulation of collecting duct Na+, K+-ATPase and K+ excretion by furosemide and piretanide: role of bradykinin. J Am Soc Nephrol 15:876–884
Cervenka L, Harrison-Bernard LM, Dipp S, Primrose G, Imig JD, El-Dahr SS (1999) Early onset salt-sensitive hypertension in bradykinin B2 receptor null mice. Hypertension 34:176–180
Dinchuk JE, Car BD, Focht RJ, Johnston JJ, Jaffee BD, Covington MB, Contel NR, Eng VM, Collins RJ, Czerniak PM, Gorry SA, Trzaskos JM (1995) Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II. Nature 378:406–409
Dyer AR, Elliott P, Shipley M (1994) Urinary electrolyte excretion in 24 hours and blood pressure in the INTERSALT Study. II estimates of electrolyte-blood pressure associations corrected for regression dilution bias The INTERSALT Cooperative Research Group. Am J Epidemiol 139:940–951
Eaton B, Konner M (1985) Paleolithic nutrition: a consideration of its nature and current implications. N Engl J Med 312:283–289
Encuesta Nacional de Salud Chile, ENS 2009–2010 [Internet] (2010) Available from: https://www.minsal.cl/portal/url/item/bcb03d7bc28b64dfe040010165012d23.pdf
Gainer JV, Morrow JD, Loveland A, King DJ, Brown NJ (1998) Effect of bradykinin-receptor blockade on the response to angiotensin-converting-enzyme inhibitor in normotensive and hypertensive subjects. N Engl J Med 339:1285–1292
He FJ, MacGregor GA (2001) Beneficial effects of potassium. Br Med J 323:497–501
Kömhoff M, Wang JL, Cheng HF, Langenbach R, McKanna JA, Harris RC, Breyer MD (2000) Cyclooxygenase-2-selective inhibitors impair glomerulogenesis and renal cortical development. Kidney Int 57:414–422
Masferrer JL, Seibert K, Zweifel B, Needleman P (1992) Endogenous glucocorticoids regulate an inducible cyclooxygenase enzyme. Proc Natl Acad Sci U S A 89:3917–3921
Mezzano S, Droguett A, Burgos ME, Ardiles LG, Flores CA, Aros CA, Caorsi I, Vio CP, Ruiz-Ortega M, Egido J (2003) Renin-angiotensin system activation and interstitial inflammation in human diabetic nephropathy. Kidney Int 64:cS64–cS70
Morham SG, Langenbach R, Loftin CD, Tiano HF, Vouloumanos N, Jennette JC, Mahler JF, Kluckman KD, Ledford A, Lee CA, Smithies O (1995) Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse. Cell 83:473–482
Vio CP, Figueroa CD (1987) Evidence for a stimulatory effect of high potassium diet on renal kallikrein. Kidney Int 31:1327–1334
Vio CP, Loyola S, Velarde V (1992) Localization of components of the kallikrein-kinin system in the kidney: relation to renal function. Hypertension 19:10–16
Vio CP, Cespedes C, Gallardo P, Masferrer JL (1997) Renal identification of cyclooxygenase-2 in a subset of thick ascending limb cells. Hypertension 30:687–692
Vio CP, An SJ, Cespedes C, McGiff JC, Ferreri NR (2001) Induction of cyclooxygenase-2 in thick ascending limb cells by adrenalectomy. J Am Soc Nephrol 12:649–658
Zhao C, Wang P, Xiao X, Chao J, Chao L, Wang DW, Zeldin DC (2003) Gene therapy with human tissue kallikrein reduces hypertension and hyperinsulinemia in fructose-induced hypertensive rats. Hypertension 42:1026–1033
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Gallardo, P.A., Vio, C.P. (2022). Pathophysiology of Hypertension or High Blood Pressure. In: Renal Physiology and Hydrosaline Metabolism. Springer, Cham. https://doi.org/10.1007/978-3-031-10256-1_12
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DOI: https://doi.org/10.1007/978-3-031-10256-1_12
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