Abstract
Liver transplantation (LT) has evolved from a semi-experimental procedure in the 1960s to become a routine intervention with excellent results in patients with both acute and chronic liver diseases. Improvements and innovations in surgical technique, graft preservation and patient selection have led to increase in indications for LT, including some conditions that only a few years ago would have been considered absolute contraindications. The progressive change in indications for LT such as the increase in non-alcoholic fatty liver disease and hepatocellular carcinoma has led to an increased focus on long-term outcomes and the notion of transplant benefit when selecting candidates. New selection and allocation systems have been developed to maximize these outcomes by matching patients to suitable grafts. Post-transplant management in the early phase is concerned mainly with surgical, infective and immunological complications whilst long-term management focuses on reducing the risk to the patient from the complications of immunosuppression such as cardiovascular disease and cancers.
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Gupta, R., O’Beirne, J. (2022). Liver Transplantation. In: Cross, T. (eds) Liver Disease in Clinical Practice. In Clinical Practice. Springer, Cham. https://doi.org/10.1007/978-3-031-10012-3_17
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