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Brain Tumor Segmentation in mpMRI Scans (BraTS-2021) Using Models Based on U-Net Architecture

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Brainlesion: Glioma, Multiple Sclerosis, Stroke and Traumatic Brain Injuries (BrainLes 2021)

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Abstract

Accurate segmentation of brain tumors from MR images has important clinical relevance. To overcome the limitations of manual segmentation, a semi-automatic or automatic approach is desirable. The current study mainly focused on task-1 defined in the BraTS'21 challenge, i.e., segmenting glioblastoma into sub-regions (the “enhancing tumor” (ET), the “tumor core” (TC), and the “whole tumor” (WT)). In the current study, deep learning models based upon UNet architecture were developed for producing tumor segmentation labels from 3D multi-parametric MRI (mpMRI) scans. During the segmentation process, the output mask resulting from the first developed Model (WT) was used to develop segmentation models for the remaining subregions. Optimizations were carried out to develop robust models, reduce computation time, and achieve high accuracy. Developed models showed high accuracy for the segmentation of tumor sub-regions on training as well as validation data.

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References

  1. Hamghalam, M., Lei, B., Wang, T.: Brain Tumor Synthetic Segmentation in 3D Multimodal MRI Scans. In: Crimi, A., Bakas, S. (eds.) BrainLes 2019. LNCS, vol. 11992, pp. 153–162. Springer, Cham (2020). https://doi.org/10.1007/978-3-030-46640-4_15

    Chapter  Google Scholar 

  2. Cancer today (2020). https://gco.iarc.fr/today/fact-sheets-cancers. Accessed 2 Aug 2021

  3. Bush, N.A.O., Chang, S.M., Berger, M.S.: Current and future strategies for treatment of glioma. Neurosurg. Rev. 40(1), 1–14 (2016). https://doi.org/10.1007/s10143-016-0709-8

    Article  Google Scholar 

  4. Li, X., Luo, G., Wang, K.: Multi-step Cascaded Networks for Brain Tumor Segmentation. In: Crimi, A., Bakas, S. (eds.) BrainLes 2019. LNCS, vol. 11992, pp. 163–173. Springer, Cham (2020). https://doi.org/10.1007/978-3-030-46640-4_16

    Chapter  Google Scholar 

  5. Zhao, Y.-X., Zhang, Y.-M., Liu, C.-L.: Bag of Tricks for 3D MRI Brain Tumor Segmentation. In: Crimi, A., Bakas, S. (eds.) BrainLes 2019. LNCS, vol. 11992, pp. 210–220. Springer, Cham (2020). https://doi.org/10.1007/978-3-030-46640-4_20

    Chapter  Google Scholar 

  6. Jiang, Z., Ding, C., Liu, M., Tao, D.: Two-Stage Cascaded U-Net: 1st Place Solution to BraTS Challenge 2019 Segmentation Task. In: Crimi, A., Bakas, S. (eds.) BrainLes 2019. LNCS, vol. 11992, pp. 231–241. Springer, Cham (2020). https://doi.org/10.1007/978-3-030-46640-4_22

    Chapter  Google Scholar 

  7. Islam, M., Vibashan, V.S., Jose, V.J.M., Wijethilake, N., Utkarsh, U., Ren, H.: Brain Tumor Segmentation and Survival Prediction Using 3D Attention UNet. In: Crimi, A., Bakas, S. (eds.) BrainLes 2019. LNCS, vol. 11992, pp. 262–272. Springer, Cham (2020). https://doi.org/10.1007/978-3-030-46640-4_25

    Chapter  Google Scholar 

  8. Sahayam, S., Krishna, N.H., Jayaraman, U.: Brain Tumour Segmentation on MRI Images by Voxel Classification Using Neural Networks, and Patient Survival Prediction. In: Crimi, A., Bakas, S. (eds.) BrainLes 2019. LNCS, vol. 11992, pp. 284–294. Springer, Cham (2020). https://doi.org/10.1007/978-3-030-46640-4_27

    Chapter  Google Scholar 

  9. Feng, X., Dou, Q., Tustison, N., Meyer, C.: Brain Tumor Segmentation with Uncertainty Estimation and Overall Survival Prediction. In: Crimi, A., Bakas, S. (eds.) BrainLes 2019. LNCS, vol. 11992, pp. 304–314. Springer, Cham (2020). https://doi.org/10.1007/978-3-030-46640-4_29

    Chapter  Google Scholar 

  10. Guo, D., Wang, L., Song, T., Wang, G.: Cascaded Global Context Convolutional Neural Network for Brain Tumor Segmentation. In: Crimi, A., Bakas, S. (eds.) BrainLes 2019. LNCS, vol. 11992, pp. 315–326. Springer, Cham (2020). https://doi.org/10.1007/978-3-030-46640-4_30

    Chapter  Google Scholar 

  11. Agravat, R.R., Raval, M.S.: Brain Tumor Segmentation and Survival Prediction. In: Crimi, A., Bakas, S. (eds.) BrainLes 2019. LNCS, vol. 11992, pp. 338–348. Springer, Cham (2020). https://doi.org/10.1007/978-3-030-46640-4_32

    Chapter  Google Scholar 

  12. Liu, S., Guo, X.: Improving Brain Tumor Segmentation with Multi-direction Fusion and Fine Class Prediction. In: Crimi, A., Bakas, S. (eds.) BrainLes 2019. LNCS, vol. 11992, pp. 349–358. Springer, Cham (2020). https://doi.org/10.1007/978-3-030-46640-4_33

    Chapter  Google Scholar 

  13. Ranjbarzadeh, R., et al.: Brain tumor segmentation based on deep learning and an attention mechanism using MRI multi-modalities brain images. Sci Rep 11, 10930 (2021). https://doi.org/10.1038/s41598-021-90428-8

    Article  Google Scholar 

  14. Havaei, M., et al.: Brain tumor segmentation with Deep Neural Networks. Med Image Anal. 35, 18–31 (2017). https://doi.org/10.1016/j.media.2016.05.004. Epub 2016 May 19 PMID: 27310171 Jan

    Article  Google Scholar 

  15. Ramya, P., Thanabal, M.S., Dharmaraja, C.: Brain tumor segmentation using cluster ensemble and deep super learner for classification of MRI. J. Ambient. Intell. Humaniz. Comput. 12(10), 9939–9952 (2021). https://doi.org/10.1007/s12652-021-03390-8

    Article  Google Scholar 

  16. Huang, Z., Zhao, Y., Liu, Y., Song, G.: GCAUNet: a group cross-channel attention residual UNet for slice based brain tumor segmentation. Biomedical Signal Processing and Control 70, 102958 (2021). ISSN 1746–8094. https://doi.org/10.1016/j.bspc.2021.102958. (https://www.sciencedirect.com/science/article/pii/S1746809421005553)

  17. Huang, Z., Liu, Y., Song, G., Zhao, Y.: GammaNet: an intensity-invariance deep neural network for computer-aided brain tumor segmentation. Optik 243, 167441 (2021). ISSN 0030–4026. https://doi.org/10.1016/j.ijleo.2021.167441. (https://www.sciencedirect.com/science/article/pii/S0030402621010706)

  18. Baid, U., et al.: The RSNA-ASNR-MICCAI BraTS 2021 Benchmark on Brain Tumor Segmentation and Radiogenomic Classification (2021). arXiv:2107.02314

  19. Menze, B.H., et al.: The Multimodal Brain Tumor Image Segmentation Benchmark (BRATS). IEEE Trans. Med. Imaging 34(10), 1993–2024 (2015). https://doi.org/10.1109/TMI.2014.2377694

    Article  Google Scholar 

  20. Bakas, S., et al.: Advancing the cancer genome atlas glioma MRI collections with expert segmentation labels and radiomic features. Nature Scientific Data 4, 170117 (2017). https://doi.org/10.1038/sdata.2017.117

    Article  Google Scholar 

  21. Ronneberger, O., Fischer, P., Brox, T., U-Net: Convolutional Networks for Biomedical Image Segmentation (2021). [online] arXiv.org. Available at: https://arxiv.org/abs/1505.04597. Accessed 16 July 2021

  22. Wang, F., Jiang, R., Zheng, L., Meng, C., Biswal, B.: 3D U-Net Based Brain Tumor Segmentation and Survival Days Prediction. In: Crimi, A., Bakas, S. (eds.) BrainLes 2019. LNCS, vol. 11992, pp. 131–141. Springer, Cham (2020). https://doi.org/10.1007/978-3-030-46640-4_13

    Chapter  Google Scholar 

  23. Chen, M., Wu, Y., Wu, J.: Aggregating Multi-scale Prediction Based on 3D U-Net in Brain Tumor Segmentation. In: Crimi, A., Bakas, S. (eds.) BrainLes 2019. LNCS, vol. 11992, pp. 142–152. Springer, Cham (2020). https://doi.org/10.1007/978-3-030-46640-4_14

    Chapter  Google Scholar 

  24. Kim, S., Luna, M., Chikontwe, P., Park, S.H.: Two-Step U-Nets for Brain Tumor Segmentation and Random Forest with Radiomics for Survival Time Prediction. In: Crimi, A., Bakas, S. (eds.) BrainLes 2019. LNCS, vol. 11992, pp. 200–209. Springer, Cham (2020). https://doi.org/10.1007/978-3-030-46640-4_19

    Chapter  Google Scholar 

  25. Bakas, S., et al.: Segmentation labels and radiomic features for the Pre-operative scans of the TCGA-GBM collection. The Cancer Imaging Archive (2017). https://doi.org/10.7937/K9/TCIA.2017.KLXWJJ1Q

    Article  Google Scholar 

  26. Bakas, S., et al.: Segmentation labels and radiomic features for the pre-operative scans of the TCGA-LGG collection. The Cancer Imaging Archive (2017). https://doi.org/10.7937/K9/TCIA.2017.GJQ7R0EF

    Article  Google Scholar 

  27. Braintumorsegmentation.org: MICCAI BRATS - The Multimodal Brain Tumor Segmentation Challenge (2022). [online] Available at: <http://braintumorsegmentation.org/>. Accessed 13 Oct 2021

  28. Sage Bionetworks: i. Synapse | Sage Bionetworks (2022). [online] Synapse.org. Available at: <https://www.synapse.org/#!Synapse:syn25829067/wiki/610865>. Accessed 13 October 2021

  29. Braintumorsegmentation.org: MICCAI BRATS - The Multimodal Brain Tumor Segmentation Challenge (2022). [online] Available at: <http://braintumorsegmentation.org/>. Accessed 13 Oct 2021.

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Acknowledgments

The authors acknowledge funding support from the Science and Engineering Research Board, Department of Science and Technology project: CRG/2019/005032.

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Correspondence to Anup Singh .

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Maurya, S., Kumar Yadav, V., Agarwal, S., Singh, A. (2022). Brain Tumor Segmentation in mpMRI Scans (BraTS-2021) Using Models Based on U-Net Architecture. In: Crimi, A., Bakas, S. (eds) Brainlesion: Glioma, Multiple Sclerosis, Stroke and Traumatic Brain Injuries. BrainLes 2021. Lecture Notes in Computer Science, vol 12963. Springer, Cham. https://doi.org/10.1007/978-3-031-09002-8_28

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  • DOI: https://doi.org/10.1007/978-3-031-09002-8_28

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