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Calmodulin Regulation of Voltage-Gated Calcium Channels

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Voltage-Gated Calcium Channels

Abstract

The ubiquitous Ca2+ sensor calmodulin (CaM) serves as a preeminent modulator of voltage-gated Ca2+ channels, exerting rapid and powerful feedback control of Ca2+ entry into cardiomyocytes and neurons. Over the past three decades, this modulation has emerged as a prototype for ion channel regulation with important physiological and pathophysiological implications. In this chapter, we summarize key findings pertaining to structural and biological mechanisms of CaM regulation, as well as elaborate on how CaV channel misregulation underlies a wide range of human diseases.

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Authors and Affiliations

  1. Department of Physiology and Cellular Biophysics, Columbia University, New York, NY, USA

    Manu Ben-Johny

  2. Department of Physiology, University of Maryland School of Medicine, Baltimore, MD, USA

    Ivy E. Dick

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  1. Manu Ben-Johny
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  1. Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada

    Gerald Werner Zamponi

  2. Department of Pathophysiology, Third Faculty of Medicine, Charles University, Prague, Czech Republic

    Norbert Weiss

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Ben-Johny, M., Dick, I.E. (2022). Calmodulin Regulation of Voltage-Gated Calcium Channels. In: Zamponi, G.W., Weiss, N. (eds) Voltage-Gated Calcium Channels . Springer, Cham. https://doi.org/10.1007/978-3-031-08881-0_9

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