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Clinical Overview of Psoriasis and Psoriatic Arthritis

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Textbook of Dermatologic Ultrasound

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Abstract

Psoriasis is a chronic and immune-mediated inflammatory disease affecting the skin and joints of approximately 2–3% of the world population, with a bimodal age distribution, compromising both sexes equally. Its cause is complex and not completely clarified; there would be genetic susceptibility on which triggering environmental factors would lead to a dysregulated inflammatory response, alterations in the skin barrier functions, and immune response that have a systemic impact, determining the appearance or progression of comorbidities. Psoriasis presents a large clinical polymorphism and a highly variable degree of individual involvement; its diagnosis is based almost entirely on its clinical characteristics and rarely requires histological confirmation. The choice of long-term therapy is determined by the severity of the disease, comorbidities, special locations, failure to previous treatments, and access to medical care. Lately, biological therapy has meant a great leap in effectiveness, even achieving complete disease resolution.

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Authors and Affiliations

  1. Department of Dermatology, Faculty of Medicine, Universidad de Chile, Santiago, Chile

    Fernando Valenzuela & Rodrigo Flores

  2. Department of Dermatology, Clinica Universidad de los Andes, Santiago, Chile

    Fernando Valenzuela

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  1. Fernando Valenzuela
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Correspondence to Fernando Valenzuela .

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  1. Institute for Diagnostic Imaging and Research of the Skin and Soft Tissues, Santiago, RM, Chile

    Ximena Wortsman

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Valenzuela, F., Flores, R. (2022). Clinical Overview of Psoriasis and Psoriatic Arthritis. In: Wortsman, X. (eds) Textbook of Dermatologic Ultrasound. Springer, Cham. https://doi.org/10.1007/978-3-031-08736-3_19

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