Abstract
Retinoblastoma is the most common childhood eye cancer with approximately 8000 new patients annually worldwide, most of whom live in low- and middle-income countries (LMICs). Early detection and urgent referral to a specialized retinoblastoma treatment center is of utmost importance in order to save life, salvage the eye, and, in selected cases, retain vision. Advances in retinoblastoma screening, detection, and management in high-income countries have resulted in dramatic improvement in disease outcome in the last 50 years. However, these changes have not been observed in LMICs, where patients present late, with advanced disease, some with distant metastasis at time of initial diagnosis. In addition, the rate of familial retinoblastoma cases is reported to be significantly lower in LMICs, probably because many do not reach a childbearing age. Given that retinoblastoma is a curable disease, these data are concerning and warrant intervention at national and international levels.
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References
Kivelä T. The epidemiological challenge of the most frequent eye cancer: retinoblastoma, an issue of birth and death. Br J Ophthalmol. 2009;93:1129–31.
Global Retinoblastoma Study Group, Fabian ID, Abdallah E, et al. Global retinoblastoma presentation and analysis by National Income Level. JAMA Oncologia. 2020;
de Jong MC, Kors WA, de Graaf P, et al. The incidence of trilateral retinoblastoma: a systematic review and meta-analysis. Am J Ophthalmol. 2015;160:1116–1126.e5.
Ophthalmology AA of 2018–2019 BCSC (Basic and Clinical Science Course), Section 04: ophthalmic pathology and intraocular tumors. (Jr RHR, MD, editors.).
Rao R, Honavar SG. Retinoblastoma. Indian J Pediatr. 2017;84:937–44.
Chawla B, Hasan F, Azad R, et al. Clinical presentation and survival of retinoblastoma in Indian children. Br J Ophthalmol. 2016;100:172–8.
Fabian ID, Johnson KP, Stacey AW, et al. Focal laser treatment in addition to chemotherapy for retinoblastoma. Cochrane Database Syst Rev. 2017;6:CD012366.
Rodriguez-Galindo C, Wilson MW, Chantada G, et al. Retinoblastoma: one world, one vision. Pediatrics. 2008;122:e763–70.
Tomar AS, Finger PT, Gallie B, et al. Global retinoblastoma treatment outcomes: association with National Income Level. Ophthalmology. 2020;
Ribeiro RC, Steliarova-Foucher E, Magrath I, et al. Baseline status of paediatric oncology care in ten low-income or mid-income countries receiving my child matters support: a descriptive study. Lancet Oncol. 2008;9:721–9.
Fabian ID, Stacey AW, Foster A, et al. Travel burden and clinical presentation of retinoblastoma: analysis of 1024 patients from 43 African countries and 518 patients from 40 European countries. Br J Ophthalmol. 2020;
Bowman RJC, Foster A, Stacey A, et al. International travel to obtain medical treatment for primary retinoblastoma: a global cohort study. Int J Cancer. 2020;
Dimaras H, Corson TW, Cobrinik D, et al. Retinoblastoma. Nat Rev Dis Primers. 2015;1:15021.
Broaddus E, Topham A, Singh AD. Incidence of retinoblastoma in the USA: 1975-2004. Br J Ophthalmol. 2009;93:21–3.
Krishna SM, Yu G-P, Finger PT. The effect of race on the incidence of retinoblastoma. J Pediatr Ophthalmol Strabismus. 2009;46:288–93.
Bowman R. Retinoblastoma: a curable, rare and deadly blinding disease. Community Eye Health. 2018;31:1–4.
Pui CH, Boyett JM, Relling MV, et al. Sex differences in prognosis for children with acute lymphoblastic leukemia. J Clin Oncol. 1999;17:818–24.
Pala L, Nezi L, De Pas T, et al. Sex differences in efficacy and toxicity of systemic cancer treatments: role of the microbiome. J Clin Oncol. 2019;37:439.
Pokhrel S, Snow R, Dong H, et al. Gender role and child health care utilization in Nepal. Health Policy (Amsterdam, Netherlands). 2005;74:100–9.
Dancer D, Rammohan A, Smith MD. Infant mortality and child nutrition in Bangladesh. Health Econ. 2008;17:1015–35.
Mitra AK, Rahman MM, Fuchs GJ. Risk factors and gender differentials for death among children hospitalized with diarrhoea in Bangladesh. J Health Popul Nutr. 2000;18:151–6.
Gilbert CE, Lepvrier-Chomette N. Gender inequalities in surgery for bilateral cataract among children in low-income countries: a systematic review. Ophthalmology. 2016;123:1245–51.
Ramakrishnan S, Khera R, Jain S, et al. Gender differences in the utilisation of surgery for congenital heart disease in India. Heart. 2011;97:1920–5.
Shetty OA, Naresh KN, Banavali SD, et al. Evidence for the presence of high risk human papillomavirus in retinoblastoma tissue from nonfamilial retinoblastoma in developing countries. Pediatr Blood Cancer. 2012;58:185–90.
Rushlow DE, Mol BM, Kennett JY, et al. Characterisation of retinoblastomas without RB1 mutations: genomic, gene expression, and clinical studies. Lancet Oncol. 2013;14:327–34.
Fletcher O, Easton D, Anderson K, et al. Lifetime risks of common cancers among retinoblastoma survivors. J Natl Cancer Inst. 2004;96:357–63.
Chawla B, Kumar K, Singh AD. Influence of socioeconomic and cultural factors on retinoblastoma. Asia Pac J Oncol Nurs. 2017;4:187–90.
Traoré F, Sylla F, Togo B, et al. Treatment of retinoblastoma in sub-Saharan Africa: experience of the paediatric oncology unit at Gabriel Toure teaching hospital and the Institute of African Tropical Ophthalmology, Bamako. Mali Pediatr Blood Cancer. 2018;65:e27101.
Hill JA, Kimani K, White A, et al. Achieving optimal cancer outcomes in East Africa through multidisciplinary partnership: a case study of the Kenyan National Retinoblastoma Strategy group. Glob Health. 2016;12:23.
Wilimas JA, Wilson MW, Haik BG, et al. Development of retinoblastoma programs in Central America. Pediatr Blood Cancer. 2009;53:42–6.
Qaddoumi I, Nawaiseh I, Mehyar M, et al. Team management, twinning, and telemedicine in retinoblastoma: a 3-tier approach implemented in the first eye salvage program in Jordan. Pediatr Blood Cancer. 2008;51:241–4.
Antillon F, Baez FL, Barr R, et al. AMOR: a proposed cooperative effort to improve outcomes of childhood cancer in Central America. Pediatr Blood Cancer. 2005;45:107–10.
Yousef YA, Al-Nawaiseh I, Mehyar M, et al. How telemedicine and centralized care changed the natural history of retinoblastoma in a developing country: analysis of 478 patients. Ophthalmology. 2021;128:130–7.
Anon. WHO | Global Initiative for Childhood Cancer. WHO. Available at: http://www.who.int/cancer/childhood-cancer/en/. Accessed 30 Aug 2020.
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Prat, D.L., Zondervan, M., Fabian, I.D. (2022). Worldwide Analysis: The Global Presentation of Retinoblastoma. In: Chawla, B.V., Aronow, M.E. (eds) Global Perspectives in Ocular Oncology. Springer, Cham. https://doi.org/10.1007/978-3-031-08250-4_3
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