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Tongue Allotransplantation

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Tongue Lesions

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Abstract

The tongue is a vital organ that is integral to many basic human functions, such as speech, eating, and swallowing. Many complex human social interactions require the proper form and function of this highly specialized and unique organ. However, the tongue is incapable of these intricate activities without the coordinated muscle activity of other key aerodigestive tract structures, namely the floor of mouth muscles, larynx, and pharynx [1].

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References

  1. Chi JJ, Haughey BH. Tongue transplantation. Curr Otorhinolaryngol Rep. 2014;2:178–83.

    Article  Google Scholar 

  2. Lutz BS, Wei FC. Microsurgical workhorse flaps in head and neck reconstruction. Clin Plast Surg. 2005;32:421–30.

    Article  PubMed  Google Scholar 

  3. Wong CH, Wei FC. Microsurgical free flap in head and neck reconstruction. Head Neck. 2010;32:1236–45.

    Article  PubMed  Google Scholar 

  4. Hanasono MM, Matros E, Disa JJ. Important aspects of head and neck reconstruction. Plast Reconstr Surg. 2014;134:968e–80e.

    Article  CAS  PubMed  Google Scholar 

  5. Goll G. Design for maximal retention of obturator prosthesis for hemimaxillectomy patients. J Prosthet Dent. 1982;48:108–9.

    Article  CAS  PubMed  Google Scholar 

  6. Keyf F. Obturator prostheses for hemimaxillectomy patients. J Oral Rehabil. 2001;28:821–9.

    Article  CAS  PubMed  Google Scholar 

  7. Chen C, Ren W, Gao L, Cheng Z, Zhang L, Li S, et al. Function of obturator prosthesis after maxillectomy and prosthetic obturator rehabilitation. Braz J Otorhinolaryngol. 2016;82:177–83.

    Article  PubMed  Google Scholar 

  8. Suzuki T, Tanaka I, Osaka R, Baba A, Sato K, Yamauchi T, et al. Preliminary study of temporal change in free flap volume after tongue reconstruction. Bull Tokyo Dent Coll. 2017;58:269–75.

    Article  PubMed  Google Scholar 

  9. Isomura ET, Nakagawa K, Mitsui R, Shogen Y, Fujita T, Kogo M. Hemi-tongue allograft transplantation in dogs. Plast Reconstr Surg Glob Open. 2020;8(4):e2767.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Dodds WJ. Physiology of swallowing. Dysphagia. 1989;3:171–8.

    Article  CAS  PubMed  Google Scholar 

  11. Lazarus CL, Logemann JA, Pauloski BR, Rademaker AW, Larson CR, Mittal BB, et al. Swallowing and tongue function following treatment for oral and oropharyngeal cancer. J Speech Lang Hear Res. 2000;43:1011–23.

    Article  CAS  PubMed  Google Scholar 

  12. Miyamoto JJ, Honda M, Saito DN, Okada T, Ono T, Ohyama K, et al. The representation of the human oral area in the somatosensory cortex: a functional MRI study. Cereb Cortex. 2006;16:669–75.

    Article  PubMed  Google Scholar 

  13. Capra NF. Mechanisms of oral sensation. Dysphagia. 1995;10:235–47.

    Article  CAS  PubMed  Google Scholar 

  14. Lam L, Samman N. Speech and swallowing following tongue cancer surgery and free flap reconstruction—a systematic review. Oral Oncol. 2013;49:507–24.

    Article  PubMed  Google Scholar 

  15. Speksnijder CM, van der Bilt A, van der Glas HW, Koole R, Merkx MAW. Tongue function in patients treated for malignancies in tongue and/or floor of mouth; a one year prospective study. Int J Oral Maxillofac Surg. 2011;40:1388–94.

    CAS  PubMed  Google Scholar 

  16. Urken ML, Moscoso JF, Lawson W, Biller HF. A systematic approach to functional reconstruction of the oral cavity following partial and total glossectomy. Arch Otolaryngol Head Neck Surg. 1994;120(6):589–601.

    Article  CAS  PubMed  Google Scholar 

  17. Haughey BH. Tongue reconstruction: concepts and practice. Laryngoscope. 1993;103:1132–41.

    Article  CAS  PubMed  Google Scholar 

  18. Woo SW, Jeong HS, Kim JP, Park JJ, Ryu J, Baek C-H. Buccinator myomucosal flap for reconstruction of glossectomy defects. Otolaryngol Head Neck Surg. 2013;149(2):226–31.

    Article  PubMed  Google Scholar 

  19. Sebastian P, Thomas S, Varghese BT, Iype EM, Balagopal PC, Mathew PC. The submental island flap for reconstruction of intraoral defects in oral cancer patients. Oral Oncol. 2008;44:1014–8.

    Article  PubMed  Google Scholar 

  20. McConnel FM, Pauloski BR, Logemann JA, Rademaker AW, Colangelo L, Shedd D, et al. Functional results of primary closure vs flaps in oropharyngeal reconstruction. Arch Otolaryngol Head Neck Surg. 1998;124:625–30.

    Article  CAS  PubMed  Google Scholar 

  21. Sultan MR, Coleman JJ. Oncologic and functional considerations of total glossectomy. Am J Surg. 1989;158:297–302.

    Article  CAS  PubMed  Google Scholar 

  22. Salibian AH, Allison G, Rappaport I. Total and subtotal glossectomy: function after microvascular reconstruction. Plast Reconstr Surg. 1989;85:513–24.

    Article  Google Scholar 

  23. Kimata Y, Sakuraba M, Hishinuma S, Ebihara S, Hayashi R, Asakage T, et al. Analysis of the relations between the shape of the reconstructed tongue and postoperative functions after subtotal or total glossectomy. Laryngoscope. 2003;113:905–9.

    Article  PubMed  Google Scholar 

  24. Mitsimponas KT, Iliopoulos C, Stockmann P, Bumiller L, Nkeenke E, Neukam FW, et al. The free scapular/ parascapular flap as a reliable method of reconstruction in the head and neck region: a retrospective analysis of 130 reconstructions performed over a period of 5 years in a single department. J Craniomaxillofac Surg. 2014;42(5):536–43.

    Article  PubMed  Google Scholar 

  25. Haughey BG, Beggs JC, Bong J, Genden EM, Buckner A, et al. Microneurovascular allotransplantation of the canine tongue. Laryngoscope. 1999;109:1461–70.

    Article  CAS  PubMed  Google Scholar 

  26. Dziegielewski PT, Ho ML, Rieger J, Singh P, Langille M, Harris JR, et al. Total glossectomy with laryngeal preservation and free flap reconstruction: objective functional outcomes and systematic review of the literature. Laryngoscope. 2013;123:140–5.

    Article  PubMed  Google Scholar 

  27. Birchall M. Tongue transplantation. Lancet. 2004;363(9422):1663.

    Article  PubMed  Google Scholar 

  28. Birchall MA, Lorenz RR, Berke GS, Genden EM, Haughey BH, Siemionow M, et al. Laryngeal transplantation in 2005: a review. Am J Transplant. 2006;6:20–6.

    Article  CAS  PubMed  Google Scholar 

  29. Alam DS, Chi JJ. Facial transplantation for massive traumatic injuries. Otolaryngol Clin N Am. 2013;46(5):883–901.

    Article  Google Scholar 

  30. Kulahci Y, Sieminow M. A new composite hemiface/mandible/tongue transplantation model in rats. Ann Plast Surg. 2010;64:114–21.

    Article  CAS  PubMed  Google Scholar 

  31. Devauchelle B, Badet L, Lengelé B, Morelon E, Teswtellin S, Michallet M, et al. First human face allograft: early report. Lancet. 2006;368:203–9.

    Article  PubMed  Google Scholar 

  32. Dubernard JM, Devauchelle B. Face transplantation. Lancet. 2008;372:603–4.

    Article  PubMed  Google Scholar 

  33. Guo S, Han Y, Zhang X, Lu B, Yi C, Zhang H, et al. Human facial allotransplantation: a 2-year follow-up study. Lancet. 2008;372:631–8.

    Article  PubMed  Google Scholar 

  34. Lantieri L, Meningaud JP, Grimbert P, Bellivier F, Lefaucheur J-P, Ortonne N, et al. Repair of the lower and middle parts of the face by composite tissue allotransplantation in a patient with massive plexiform neurofibroma: a 1-year follow-up study. Lancet. 2008;372:639–45.

    Article  PubMed  Google Scholar 

  35. Siemionow M, Papay F, Alam D, Bernard S, Djohan R, Gordon C, et al. Near-total human face transplantation for a severely disfigured patient in the USA. Lancet. 2009;374:203–9.

    Article  PubMed  Google Scholar 

  36. Kumamaru KK, Sisk GC, Mitsouras D, Schultz K, Steigner ML, George E, et al. Vascular communications between donor and recipient tissues after successful full face transplantation. Am J Transplant. 2014;14:711–9.

    Article  CAS  PubMed  Google Scholar 

  37. Kermer C, Watzinger F, Oeckher M. Tongue transplantation: 10 month follow-up. Transplantation. 2008;85(4):654–5.

    Article  PubMed  Google Scholar 

  38. Siemionow M. The miracle of face transplantation after 10 years. Br Med Bull. 2016;120:5–14.

    Article  PubMed  Google Scholar 

  39. Nagaraju S, Grethlein SJ, Vaishnav S, Sharfuddin AA, Pawelso JA, Fridell JA. Case report: primary de novo sarcoma in transplant pancreas allograft. Transplant Proc. 2017;49:2352–4.

    Article  CAS  PubMed  Google Scholar 

  40. Singh P, Visger Von J, Prosek J, Olencki T, Pandey D, Rovin B, et al. Preserved renal allograft function and successful treatment of metastatic Merkel cell cancer post nivolumab therapy. Transplantation. 2019;103:e52–3.

    Article  PubMed  Google Scholar 

  41. Capanna R, Totti F, Van der Geest IC, Muller DA. Scapular allograft reconstruction after total scapulectomy: surgical technique and functional results. J Shoulder Elb Surg. 2015;24:e203–11.

    Article  Google Scholar 

  42. Pesenti S, Peltier E, Pomero V, Authier G, Roscigni L, Wiehweger E, et al. Knee function after limb salvage surgery for malignant bone tumor: comparison of megaprosthesis and distal femur allograft with epiphysis sparing. Int Orthop. 2018;42:427–36.

    Article  PubMed  Google Scholar 

  43. Campanacci DA. CORR insights: proximal tibia reconstruction after bone tumor resection: are survivorship and outcomes of endoprosthetic replacement and osteoarticular allograft similar? Clin Orthop Relat Res. 2017;475:683–5.

    Article  PubMed  Google Scholar 

  44. Quilichini L, Hivelin M, Benjoar MD, et al. Restoration of the donor after face graft procurement for allotransplantation: report on the technique and outcomes of seven cases. Plast Reconstr Surg. 2012;129(5):1105–11.

    Article  CAS  PubMed  Google Scholar 

  45. Petruzzo P, Lanzetta M, Dubernard JM, Landin L, Cavadas P, Margreiter R, et al. The international registry on hand and composite tissue transplantation. Transplantation. 2008;90(12):1590–4.

    Article  Google Scholar 

  46. Sieminow M, Kulahci Y. Facial transplantation. Semin Plast Surg. 2007;21:259–68.

    Article  Google Scholar 

  47. Ulusal BG, Ulusal AE, Ozmen S, Zins JE, Siemionow MZ, et al. A new composite facial and scalp transplantation model in rats. Plast Reconstr Surg. 2003;1112:1302–11.

    Article  Google Scholar 

  48. Kermer C, Oeckher M. Wien Klin Wochenschr. 2004;116:643–4. German. English translation.

    Article  PubMed  Google Scholar 

  49. Day TA, Tarr C, Zealear D, Burkey BB, Sullivan CA. Tongue replantation in an animal model. Microsurgery. 2000;20:105–8.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Faculty of Medicine, Alexandria University, Alexandria, Egypt

    Mahmoud F. Sakr

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  1. Mahmoud F. Sakr
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Sakr, M.F. (2022). Tongue Allotransplantation. In: Tongue Lesions. Springer, Cham. https://doi.org/10.1007/978-3-031-08198-9_19

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  • DOI: https://doi.org/10.1007/978-3-031-08198-9_19

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-08197-2

  • Online ISBN: 978-3-031-08198-9

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