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Glycine

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Neurochemistry in Clinical Practice

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Abstract

Glycine is the simplest and smallest of amino acids. It functions as an inhibitory neurotransmitter in the central nervous system and also facilitates excitatory potential at the N-methyl-D-aspartic acid (NMDA) receptors, along with glutamate. It has anti-inflammatory, cytoprotective, and immunomodulatory properties. It is also required to synthesize collagen, purines, creatinine, heme, and other amino acids like serine and glutathione. In this chapter, we outline the historical aspects, the neurochemical properties, receptor functioning, metabolism, pharmacological, and clinical aspects of glycine in the nervous system.

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Acknowledgments

All the pictures in this chapter were prepared using Biorender premium software. The tables were redrawn using information from the reference article mentoned alongside them.

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Authors and Affiliations

  1. Sree Gokulam Medical College & Research Foundation, Trivandrum, Kerala, India

    Pretty Sara Idiculla

  2. Mountain View Regional Medical Center, Las Cruces, NM, USA

    Pretty Sara Idiculla

  3. Department of Neurology, UT College of Medicine-Chattanooga/Erlanger Health System, Chattanooga, TN, USA

    Elanagan Nagarajan

  4. Pediatrics—Division of Medical Genetics, Duke University Medical Center, Durham, NC, USA

    Sireesha Murala

  5. Department of Neurology, University of South Carolina School of Medicine-Prisma Health, Columbia, SC, USA

    Pradeep C. Bollu

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  1. Pretty Sara Idiculla
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  1. Department of Neurology, University of South Carolina School of Medicine, Prisma Health, Columbia, SC, USA

    Pradeep C. Bollu

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Idiculla, P.S., Nagarajan, E., Murala, S., Bollu, P.C. (2022). Glycine. In: Bollu, P.C. (eds) Neurochemistry in Clinical Practice. Springer, Cham. https://doi.org/10.1007/978-3-031-07897-2_6

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