Abstract
Capsicum annuum is a well-known spice in different areas of the world from old times due to its specific taste, color, and aroma. It has been used in most of the kitchens and dietary products. The objective of this chapter is to review the medicinal and pharmacological properties along with botanical properties and chemical composition of C. annuum. It contains capsaicinoids (capsaicin, dihydrocapsaicin), carotenoids (lutein, zeaxanthin, capsorubin, β-carotene), flavonoids (quercetin, kaempferol, catechin, epicatechin, rutin, luteolin), and steroid saponins (capsicidine, capsicoside E, F, G). Major constituents of C. annuum essential oil are capsiamide and acetic acid identified using GC/MS. It has been reported that C. annuum has antioxidant, antibacterial, antiviral, antiproliferative, anti-adipogenic, antimutagenic, enzyme inhibitory, anti-inflammatory, hepatoprotective, antidiabetic, renoprotective, hypocholesterolemic, antitumor, anti-obesity, analgesic, food craving, and anti-reflux activities. C. annuum has been accepted with GRAS status through FEMA and is confirmed through the FDA for usage as “spices and other natural seasonings and flavorings” and “color additive” in food.
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References
Ahuja KD, Ball MJ. Effects of daily ingestion of chilli on serum lipoprotein oxidation in adult men and women. Br J Nutr. 2006;96(2):239–42.
Ali ZA. Folk veterinary medicine in Moradabad District/Uttar Pradesh, India. Fitoterapia. 1999;70:340–7.
Basu SK, De AK. Capsicum: historical and botanical perspectives. In: De AK, editor. Capsicum: the genus capsicum – medicinal and aromatic plants- industrial profiles, vol. I. New York: Taylor & Francis Inc.; 2003. p. 1–15.
Batiha GES, Alqahtani A, Ojo OA, Shaheen HM, Wasef L, Elzeiny M, Ismail M, Shalaby M, Murat T, Zaragoza-Bastida A, Rivero-Perez N, Beshbishy AM, Kasozi KI, Jeandet P, Hetta HF. Biological properties, bioactive constituents, and pharmacokinetics of some Capsicum spp. and capsaicinoids. Int J Mol Sci. 2020;21(15):5179.
Baytop A. Capsicum L. In: Davis PH, editor. Flora of Turkey and the East Aegean Islands, vol. VI. Edinburgh: Edinburgh University Press; 1978. p. 443.
Baytop T. Türkiye’de Bitkileri ile Tedavi (Geçmişte ve Bugün). İstanbul: Nobel Tıp Kitapevleri; 1999.
Bazid S, Negm A, Youssef M. Assessment of the antiproliferative activity, cell-cycle arrest, and apoptotic induction by Capsicum annuum on breast cancer cells. World J Pharm Pharm Sci. 2019;8(9):55–71.
Cao YP, Zhang D. Analysis of volatile compounds in oleoresin obtained from wind-dried and baked chilli (Capsicum annuum L.) using solid-phase micro-extraction coupled with gas chromatography-mass [J]. Sci Technol Food Ind. 2011;1:108–11.
Chaiyata P, Puttadechakum S, Komindr S. Effect of chili pepper (Capsicum frutescens) ingestion on plasma glucose response and metabolic rate in thai. J Med Assoc Thail. 2003;86:854–60.
Chanda S, Bashir M, Babbar S, Koganti A, Bley K. In vitro hepatic and skin metabolism of capsaicin. Drug Metab Dispos. 2008;36(4):670–5.
Chen L, Kang YH. In vitro inhibitory potential against key enzymes relevant for hyperglycemia and hypertension of red pepper (Capsicum annuum L.) including pericarp, placenta, and stalk. J Food Biochem. 2014;38(3):300–6.
Civan M, Kumcuoglu S. Green ultrasound-assisted extraction of carotenoid and capsaicinoid from the pulp of hot pepper paste based on the bio-refinery concept. LWT. 2019;113:108320.
Cortright DN, Szallasi A. Biochemical pharmacology of the vanilloid receptor TRPV1. Eur J Biochem. 2004;271(10):1814–9.
Cruz L, Castaneda-Hernandez G, Navarrete A. Ingestion of chili pepper (Capsicum annuum) reduces salicylate bioavailability after oral aspirin administration in the rat. Can J Physiol Pharmacol. 1999;7(6):441–6.
Das M, Basu S, Banerjee B, Jana K, Sen A, Datta G. Renoprotective effect of Capsicum annum against ethanol-induced oxidative stress and renal apoptosis. J Food Biochem. 2021;45(3):e13325.
Doğan ANC, Çelik E, Kılıçle PA, Atalay E, Sağlam AG, Doğan A, Otlu S. Antibacterial effect of hot peppers (Capsicum annuum, Capsicum annuum var globriusculum, Capsicum frutescens) on some arcobacter, campylobacter and helicobacter species. Pak Vet J. 2018;38(3)
EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS). Scientific Opinion on the re-evaluation of paprika extract (E 160c) as a food additive. EFSA J. 2015;13(12):4320.
EMA Monographs. Community herbal monograph on Capsicum annuum L. var. minimum (Miller) Heiser and small fruited varieties of Capsicum frutescens L., fructus. EMA/HMPC/674139/2013; 2014.
Farhoudi R, Mehrnia MA, Lee DJ. Antioxidant activities and bioactive compounds of five Jalopeno peppers (Capsicum annuum) cultivars. Nat Prod Res. 2019;33(6):871–4.
Ghimire K, Bastakoti RR. Ethnomedicinal knowledge and healthcare practices among the Tharus of Nawalparasi district in Central Nepal. For Ecol Manag. 2009;257:2066–72.
Govindarajan VS, Sathyanarayana MN. Capsicum—production, technology, chemistry, and quality. Part V. impact on physiology, pharmacology, nutrition, and metabolism; structure, pungency, pain, and desensitization sequences. Crit Rev Food Sci Nutr. 1991;29(6):435–74.
Gupta RS, Dixit VP, Dobhal MP. Hypocholesterolaemic effect of the oleoresin of Capsicum annum L. in gerbils (Meriones hurrianae Jerdon). Phytother Res. 2002;16(3):273–5.
Hafiz TA, Mubaraki M, Dkhil M, Al-Quraishy S. Antiviral activities of Capsicum annuum methanolic extract against herpes simplex virus 1 and 2. Pak J Zool. 2017;49(1):251.
Hamed M, Kalita D, Bartolo ME, Jayanty SS. Capsaicinoids, polyphenols and antioxidant activities of Capsicum annuum: comparative study of the effect of ripening stage and cooking methods. Antioxidants. 2019;8(9):364.
Hernández-Ortega M, Ortiz-Moreno A, Hernández-Navarro MD, Chamorro-Cevallos G, Dorantes-Alvarez L, Necoechea-Mondragón H. Antioxidant, antinociceptive, and anti-inflammatory effects of carotenoids extracted from dried pepper (Capsicum annuum L.). J Biomed Biotechnol. 2012;2012
Hornero-Méndez D, Gómez-Ladrón de Guevara R, Minguez-Mosquera MI. Carotenoid biosynthesis changes in five red pepper (Capsicum annuum L.) cultivars during ripening. Cultivar selection for breeding. J Agric Food Chem. 2000;48(9):3857–64.
Inoue T, Umemura T, Maeda M, Ishii Y, Okamura T, Tasaki M, Nishikawa A. Safety assessment of dietary administered paprika color in combined chronic toxicity and carcinogenicity studies using F344 rats. Food Chem Toxicol. 2008;46(8):2689–93.
Iorizzi M, Lanzotti V, Ranalli G, De Marino S, Zollo F. Antimicrobial furostanol saponins from the seeds of Capsicum annuum L. var. acuminatum. J Agric Food Chem. 2002;50(15):4310–6.
Jaradat N. Ethnopharmacological survey of natural products in Palestine. AnNajah University. J Nat Sci Res. 2005;19:13–67.
Kakutani R, Hokari S, Nishino A, Ichihara T, Sugimoto K, Takaha T, Takashi K, Maoka T. Effect of oral paprika xanthophyll intake on abdominal fat in healthy overweight humans: a randomized, double-blind, placebo-controlled study. J Oleo Sci. 2018;ess18076
Kawada T, Suzuki T, Takahashi M, Iwai K. Gastrointestinal absorption and metabolism of capsaicin and dihydrocapsaicin in rats. Toxicol Appl Pharmacol. 1984;72(3):449–56.
Khan FA, Mahmood T, Ali M, Saeed A, Maalik A. Pharmacological importance of an ethnobotanical plant: Capsicum annuum L. Nat Prod Res. 2014;28(16):1267–74.
Kim JS, Ha TY, Kim S, Lee SJ, Ahn J. Red paprika (Capsicum annuum L.) and its main carotenoid capsanthin ameliorate impaired lipid metabolism in the liver and adipose tissue of high-fat diet-induced obese mice. J Funct Foods. 2017;31:131–40.
Kirtikar K, Basu B. Indian medicinal plants. 2nd ed. M/S Bishen Singh Pal Singh: Delhi; 1975. p. 1465–72.
Korkutata NF, Kavaz A. A comparative study of ascorbic acid and capsaicinoid contents in red hot peppers (Capsicum annum L.) grown in southeastern Anatolia region. Int J Food Prop. 2015;18(4):725–34.
Maoka T, Mochida K, Kozuka M, Ito Y, Fujiwara Y, Hashimoto K, Enjo F, Ogata M, Nobukuni Y, Tokuda H, Nishino H. Cancer chemopreventive activity of carotenoids in the fruits of red paprika Capsicum annuum L. Cancer Lett. 2001;172(2):103–9.
Materska M, Piacente S, Stochmal A, Pizza C, Oleszek W, Perucka I. Isolation and structure elucidation of flavonoid and phenolic acid glycosides from pericarp of hot pepper fruit Capsicum annuum L. Phytochemistry. 2003;63(8):893–8.
Meghvansi MK, Siddiqui S, Khan MH, Gupta VK, Vairale MG, Gogoi HK, Singh L. Naga chilli: a potential source of capsaicinoids with broad-spectrum ethnopharmacological applications. J Ethnopharmacol. 2010;132(1):1–14.
Mesfin F, Demissew S, Teklehaymanot T. An ethnobotanical study of medicinal plants in Wonago Woreda, SNNPR. Ethiopia J Ethnobiol Ethnomedicine. 2009;5:28. https://doi.org/10.1186/1746-4269-5-28.
Mohammed A, Koorbanally N, Md SI. Anti-diabetic effect of Capsicum annuum L. fruit acetone fraction in a type 2 diabetes model of rats. Acta Pol Pharm. 2017;74(6):1767–79.
Mózsik G, Past T, Salam OMA, Kuzma M, Perjési P. Interdisciplinary review for correlation between the plant origin capsaicinoids, non-steroidal antiinflammatory drugs, gastrointestinal mucosal damage and prevention in animals and human beings. Inflammopharmacology. 2009;17(3):113–50.
Nishino A, Sugimoto K, Sambe H, Ichihara T, Takaha T, Kuriki T. Effects of dietary paprika xanthophylls on ultraviolet light-induced skin damage: a double-blind placebo-controlled study. J Oleo Sci. 2018;ess17265
Patcharatrakul T, Kriengkirakul C, Chaiwattanarat T, Gonlachanvit S. Acute effects of red chili, a natural capsaicin receptor agonist, on gastric accommodation and upper gastrointestinal symptoms in healthy volunteers and gastroesophageal reflux disease patients. Nutrients. 2020;12(12):3740.
PDR for Herbal Medicines. 4ed. Montvale: Thomson Healthcare; 2000.
Pieroni A, Quave C, Nebel S, Heinrich M. Ethnopharmacy of the ethnic Albanians (Arbereshe) of northern Basilicata. Italy Fitoterapia. 2002;73:217–41.
Priya AS, Anitha A. In vivo hepatoprotective effect of ethanolic extract of Capsicum annuum L. red variety against paracetamol induced hepatotoxicity in male wistar albino rats. Eur J Biomed Pharm Sci. 2017;4:326–32.
Reyes-Escogido MDL, Gonzalez-Mondragon EG, Vazquez-Tzompantzi E. Chemical and pharmacological aspects of capsaicin. Molecules. 2011;16(2):1253–70.
Rodríguez-Rodríguez E, Sánchez-Prieto M, Olmedilla-Alonso B. Assessment of carotenoid concentrations in red peppers (Capsicum annuum) under domestic refrigeration for three weeks as determined by HPLC-DAD. Food Chem X. 2020;6:100092.
Salehi B, Hernández-Álvarez AJ, del Mar CM, Martorell M, Ramírez-Alarcón K, Melgar-Lalanne G, Matthewsg KR, Sharifi-Radh M, Setzeri WN, Nadeemj M, Yousaf Z, Sharifi-Rad J. Potential phytopharmacy and food applications of Capsicum spp.: a comprehensive review. Nat Prod Commun. 2018;13(11):1934578X1801301133.
Shah R, Pande PC, Tiwari L. Traditional veterinary herbal medicines of western part of Almora district, Uttarakhand Himalaya. Indian J Tradit Knowl. 2008;7:355–9.
Shinn-Nen J, Rosa LH, Huei L, Shun-Jen T. The correlation between the antioxidation and the antimutagenicity of carotenoids from chili against food mutagen IQ. Nutr Sci J. 1998;23(4):357–75.
Singletary K. Red pepper: overview of potential health benefits. Nut Today. 2011;46:33–47.
Sung J, Bang MH, Lee J. Bioassay-guided isolation of anti-adipogenic compounds from defatted pepper (Capsicum annuum L.) seeds. J Funct Foods. 2015;14:670–5.
Sung J, Yu W, Lee J. Effects of capsicoside G isolated from pepper seeds on lipolysis and fatty acid oxidation-related gene expression in 3T3-L1 adipocytes. J Food Biochem. 2018;42(6):e12640.
Suresh D, Srinivasan K. Tissue distribution & elimination of capsaicin, piperine & curcumin following oral intake in rats. Indian J Med Res. 2010;131(5)
Vasudevan K, Vembar S, Veeraraghavan K, Haranath PS. Influence of intragastric perfusion of aqueous spice extracts on acid secretion in anesthetized albino rats. Indian J Gastroenterol. 2000;19(2):53–6.
Vera-Guzmán AM, Aquino-Bolaños EN, Heredia-García E, Carrillo-Rodríguez JC, Hernández-Delgado S, Chávez-Servia JL. Flavonoid and capsaicinoid contents and consumption of mexican chili pepper (Capsicum annuum L.) landraces. In: Flavonoids-from biosynthesis to human health. London: InTechOpen; 2017. p. 405–37.
Vijayalakshmi K, Shyamala R, Thirumurugan V, Sethuraman M, Rajan S, Badami S, Mukherjee PK. Physico-phytochemical investigation and anti-inflammatory screening of Capsicum annum L. and Hemidesmus indicus (Linn.) R. Br Anc Sci Life. 2010;29(4):35.
Watanebe J, Kawabata J, Kasai T. 9-Oxooctadeca-10, 12-dienoic acids as acetyl-CoA carboxylase inhibitors from red pepper (Capsicum annuum L.). Biosci Biotechnol Biochem. 1999;63(3):489–93.
Weerapan Khovidhunkit MD. Pharmacokinetic and the effect of capsaicin in Capsicum frutescens on decreasing plasma glucose level. J Med Assoc Thail. 2009;92(1):108–13.
Zhou Y, Gao X, Small DM, Chen H. Extreme spicy food cravers displayed increased brain activity in response to pictures of foods containing chili peppers: an fMRI study. Appetite. 2019;142:104379.
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Yuca, H. (2022). Capsicum annuum L.. In: Gürağaç Dereli, F.T., Ilhan, M., Belwal, T. (eds) Novel Drug Targets With Traditional Herbal Medicines. Springer, Cham. https://doi.org/10.1007/978-3-031-07753-1_7
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