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The Cross-Talk between Epigenetic Gene Regulation and Signaling Pathways Regulates Cancer Pathogenesis

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Metabolism and Epigenetic Regulation: Implications in Cancer

Part of the book series: Subcellular Biochemistry ((SCBI,volume 100))

Abstract

Cancer begins due to uncontrolled cell division. Cancer cells are insensitive to the signals that control normal cell proliferation. This uncontrolled cell division is due to the accumulation of abnormalities in different factors associated with the cell division, including different cyclins, cell cycle checkpoint inhibitors, and cellular signaling. Cellular signaling pathways are aberrantly activated in cancer mainly due to epigenetic regulation and post-translational regulation. In this chapter, the role of epigenetic regulation in aberrant activation of PI3K/AKT, Ras, Wnt, Hedgehog, Notch, JAK/STAT, and mTOR signaling pathways in cancer progression is discussed. The role of epigenetic regulators in controlling the upstream regulatory proteins and downstream effector proteins responsible for abnormal cellular signaling-mediated cancer progression is covered in this chapter. Similarly, the role of signaling pathways in controlling epigenetic gene regulation-mediated cancer progression is also discussed. We have tried to ascertain the current status of potential epigenetic drugs targeting several epigenetic regulators to prevent different cancers.

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  1. Snigdha Samanta and Rumpa Mahata contributed equally with all other contributors.

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  1. Molecular Oncology Laboratory, National Centre for Cell Science, NCCS Complex, S. P. Pune University Campus, Ganeshkhind Road, Pune, Maharashtra, India

    Snigdha Samanta, Rumpa Mahata & Manas Kumar Santra

  2. Department of Biotechnology, Savitribai Phule Pune University, Pune, Maharashtra, India

    Snigdha Samanta & Rumpa Mahata

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  1. Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India

    Tapas Kumar Kundu

  2. Biophysics and Structural Genomics Division, Saha Institute of Nuclear Physics, Kolkata, India

    Chandrima Das

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Samanta, S., Mahata, R., Santra, M.K. (2022). The Cross-Talk between Epigenetic Gene Regulation and Signaling Pathways Regulates Cancer Pathogenesis. In: Kundu, T.K., Das, C. (eds) Metabolism and Epigenetic Regulation: Implications in Cancer. Subcellular Biochemistry, vol 100. Springer, Cham. https://doi.org/10.1007/978-3-031-07634-3_13

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