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Applications of 3D Printing in Periodontal Tissue Regeneration

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3D Printing in Oral Health Science

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Abstract

The use of 3D printing for periodontal regeneration is still in its infancy. Thorough knowledge of the biological mechanisms and 3D printing systems and materials is necessary to effectively translate this technology into treatment. This systematic review summarizes evidence from published animal and human studies that have assessed the application of 3D printing for periodontal regeneration. The literature search was conducted in PubMed database from inception till April 2021 for animal and human studies evaluating 3D printing for periodontal regeneration. The SYRCLE’s risk of bias tool was used to assess the risk of bias in the included animal studies. A total of 164 articles were obtained using the above search strategy, out of which 12 articles (11 animal studies and 1 human study) fulfilled the inclusion criteria and were, thus, included in the present systematic review. In all, 233 animal subjects were used in which periodontal bony defects were ectopic defects followed by orthotopic defects. Fused deposition modeling was the most used 3D-printing technology followed by microextrusion. About 11 animal studies reported favorable clinical outcomes and limited serious complications. Most animal studies had a low risk of bias in terms of maintaining homogeneity in baseline characteristics and the selective reporting parameter. The only human study had a large periodontal osseous defect treated with a 3D-printed (selective laser sintering) polymer scaffold with good short-term but poor long-term results. Nonetheless, these studies provide important data for the efficacy of 3D-printing technology and lay the foundation for further innovation and investigation.

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Authors and Affiliations

  1. Periodontics Division, Centre for Dental Education and Research, All India Institute of Medical Sciences, New Delhi, India

    Kunaal Dhingra, Kanika Makker & Bhumika Gumber

  2. Viral Research and Diagnostic Laboratory, Department of Microbiology, Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital, New Delhi, India

    Flora Verma

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  1. Kunaal Dhingra
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  2. Kanika Makker
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  3. Flora Verma
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  4. Bhumika Gumber
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Editors and Affiliations

  1. All India Institute of Medical Sciences, New Delhi, India

    Prabhat Kumar Chaudhari

  2. North Eastern Hill University, Shillong, India

    Dinesh Bhatia

  3. All India Institute of Medical Sciences, Bhubaneswar, India

    Jitendra Sharan

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Dhingra, K., Makker, K., Verma, F., Gumber, B. (2022). Applications of 3D Printing in Periodontal Tissue Regeneration. In: Chaudhari, P.K., Bhatia, D., Sharan, J. (eds) 3D Printing in Oral Health Science. Springer, Cham. https://doi.org/10.1007/978-3-031-07369-4_7

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  • DOI: https://doi.org/10.1007/978-3-031-07369-4_7

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  • Online ISBN: 978-3-031-07369-4

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