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Bioprinting Applications in Craniofacial Regeneration

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3D Printing in Oral Health Science

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Abstract

Tissue engineering and regenerative medicine (TERM) research has advanced significantly with the development of three-dimensional (3D) printing technology. Specifically, 3D bioprinting provides additional benefits and improvement to 3D printing by incorporating the ability to include cells into the process, creating a cell-laden ink, termed bioink. By incorporating cells in conjunction with the superior temporospatial precision of 3D printing, scientists and clinicians have the potential to print live tissues with sophisticated structures and microarchitectures. While 3D bioprinting is still in its early phase, with limited preclinical animal and human studies, it has been proposed as a promising tool for TERM research in many areas of medicine and dentistry, including craniofacial, oral, and dental (DOC) tissue regeneration. This chapter aims to provide a comprehensive overview of major concepts in 3D bioprinting including its armamentarium, types of bioprinters, bioprinting process, clinical applications in craniofacial regeneration, limitations, and future perspectives.

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Authors and Affiliations

  1. Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Harvard University, Boston, MA, USA

    David T. Wu

  2. Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA

    David T. Wu

  3. Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA

    David T. Wu

  4. Craniofacial Stem Cells and Tissue Engineering Laboratory, Faculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, QC, Canada

    David T. Wu & Simon D. Tran

  5. New York University College of Dentistry, New York University, New York, NY, USA

    Hieu M. Pham

  6. Dr. Gerald Niznick College of Dentistry, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada

    Owen Tao

  7. Faculty of Medicine, University Laval, Quebec, QC, Canada

    Kevin Y. Wu

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  4. Kevin Y. Wu
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  5. Simon D. Tran
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Correspondence to Simon D. Tran .

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  1. All India Institute of Medical Sciences, New Delhi, India

    Prabhat Kumar Chaudhari

  2. North Eastern Hill University, Shillong, India

    Dinesh Bhatia

  3. All India Institute of Medical Sciences, Bhubaneswar, India

    Jitendra Sharan

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Wu, D.T., Pham, H.M., Tao, O., Wu, K.Y., Tran, S.D. (2022). Bioprinting Applications in Craniofacial Regeneration. In: Chaudhari, P.K., Bhatia, D., Sharan, J. (eds) 3D Printing in Oral Health Science. Springer, Cham. https://doi.org/10.1007/978-3-031-07369-4_10

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  • DOI: https://doi.org/10.1007/978-3-031-07369-4_10

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  • Print ISBN: 978-3-031-07368-7

  • Online ISBN: 978-3-031-07369-4

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