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Particle Therapy for Head and Neck Sarcomas

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Radiation Therapy for Sarcomas and Skin Cancers

Part of the book series: Practical Guides in Radiation Oncology ((PGRO))

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Abstract

Bone and soft tissue sarcoma of the head and neck region can be challenging to treat, as the majority of such tumors originate in locations that preclude R0 resection with sufficient surgical margins. High-dose radiation therapy is required for local disease control due to the lack of sensitivity of many of these tumors (such as chordoma and osteosarcoma) to ionizing radiation. However, doses that are sufficient for disease control may endanger critical organs at risk (OARs), including optic nerves, optic chiasm, and cochlea. Accelerated charged particle beams (e.g., proton and carbon ion beams) have a physical property that allows more focused dose distribution to the tumor area while spearing OARs as compared to photon beam. Such property of accelerated particle beams makes dose escalation possible for head and neck sarcoma irradiation thereby improving therapeutic ratio. Furthermore, the higher relative biological effectiveness of charged particle beams may also improve local control of more radioresistant tumors. In this chapter, the techniques and dose recommendations as well as major published supporting data for use of charged particle beam radiotherapy for bone and soft tissue sarcoma in the head and neck will be described.

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Abbreviations

CIRT:

Carbon ion radiotherapy

IMCT:

Intensity-modulated CIRT

IMPT:

Intensity-modulated proton radiotherapy

KPS:

Karnofsky performance scale

MFO:

Multifield optimization

PBRT:

Particle beam radiation therapy

PBS:

Pencil beam scanning

PFS:

Progress-free survival

SFO:

Single-field optimization

References

  1. Barker JL Jr, Paulino AC, Feeney S, et al. Locoregional treatment for adult soft tissue sarcomas of the head and neck: an institutional review. Cancer J. 2003;9(1):49–57.

    Article  Google Scholar 

  2. Le QT, Fu KK, Kroll S, et al. Prognostic factors in adult soft-tissue sarcomas of the head and neck. Int J Radiat Oncol Biol Phys. 1997;37(5):975–84.

    Article  Google Scholar 

  3. Tsujii H, Kamada T, Baba M, et al. Clinical advantages of carbon-ion radiotherapy. New J Phys. 2008;10:075009.

    Article  Google Scholar 

  4. Kanai T, Endo M, Minohara S, et al. Biophysical characteristics of HIMAC clinical irradiation system for heavy-ion radiation therapy. Int J Radiat Oncol Biol Phys. 1999;44:201–10.

    Article  Google Scholar 

  5. Elsasser T, Kramer M, Scholz M. Accuracy of the local effect model for the prediction of biologic effects of carbon ion beams in vitro and in vivo. Int J Radiat Oncol Biol Phys. 2008;71:866–72.

    Article  Google Scholar 

  6. Jones B. A simpler energy transfer efficiency model to predict relative biological effect for protons and heavier ions. Front Oncol. 2015;5:184.

    Article  Google Scholar 

  7. Stacchiotti S, Sommer J, Chordoma Global Consensus Group. Building a global consensus approach to chordoma: a position paper from the medical and patient community. Lancet Oncol. 2015;16(2):e71–83. https://doi.org/10.1016/S1470-2045(14)71190-8.

    Article  Google Scholar 

  8. Nieder C, Milas L, Ang KK. Tissue tolerance to reirradiation. Semin Radiat Oncol. 2000;10(3):200–9.

    Article  Google Scholar 

  9. Jingu K, Tsujii H, Mizoe JE, et al. Carbon ion radiation therapy improves the prognosis of unresectable adult bone and soft-tissue sarcoma of the head and neck. Int J Radiat Oncol Biol Phys. 2012;82(5):2125–31.

    Article  Google Scholar 

  10. Yang J, Gao J, Qiu X, et al. Intensity-modulated proton and carbon-ion radiation therapy in the management of head and neck sarcomas. Cancer Med. 2019;00:1–13.

    Google Scholar 

  11. Ciernik IF, Niemierko A, Harmon DC, et al. Proton-based radiotherapy for unresectable or incompletely resected osteosarcoma. Cancer. 2011;117:4522–30.

    Article  Google Scholar 

  12. Kamada T, Tsujii H, Tsuji H, et al. Efficacy and safety of carbon ion radiotherapy in bone and soft tissue sarcomas. J Clin Oncol. 2002;20(22):4466–71.

    Article  Google Scholar 

  13. Matsumoto K, Imai R, Kamada T, et al. Impact of carbon ion radiotherapy for primary spinal sarcoma. Cancer. 2013;119(19):3496–503.

    Article  Google Scholar 

  14. Imai R, Kamada T, Araki N. Carbon ion radiotherapy for unresectable localized axial soft tissue sarcoma. Cancer Med. 2018;7(9):4308–14.

    Article  Google Scholar 

  15. Kozak KR, Adams J, Krejcarek SJ, et al. A dosimetric comparison of proton and intensity-modulated photon radiotherapy for pediatric parameningeal rhabdomyosarcomas. Int J Radiat Oncol Biol Phys. 2009;74(1):179–86.

    Article  Google Scholar 

  16. Leiser D, Calaminus G, Malyapa R, et al. Tumor control and quality of life in children with rhabdomyosarcoma treated with pencil beam scanning proton therapy. Radiother Oncol. 2016;120(1):163–8.

    Article  Google Scholar 

  17. Weber DC, Ares C, Albertini F, et al. Pencil beam scanning proton therapy for pediatric Para-meningeal rhabdomyosarcomas: clinical outcome of patients treated at the Paul Scherrer Institute. Pediatr Blood Cancer. 2016;63:1731–6.

    Article  Google Scholar 

  18. Hug E, Loredo LN, Slater JD, et al. Proton radiation therapy for chordomas and chondrosarcomas of the skull base. J Neurosurg. 1999;91:432–9.

    Article  Google Scholar 

  19. Guan X, Gao J, Hu J, et al. The preliminary results of proton and carbon ion therapy for chordoma and chondrosarcoma of the skull base and cervical spine. Radiat Oncol. 2019;14(1):206.

    Article  Google Scholar 

  20. Munzenrider JE, Liebsch NJ. Proton therapy for tumors of the skull base. Strahlenther Onkol. 1999;175(2):57–63.

    Article  Google Scholar 

  21. Ares C, Hug EB, Lomax AJ, et al. Effectiveness and safety of spot scanning proton radiation therapy for chordomas and chondrosarcomas of the skull base: first long-term report. Int J Radiat Oncol Biol Phys. 2009;75:1111–8.

    Article  Google Scholar 

  22. Weber DC, Malyapa R, Albertini F, et al. Long term outcomes of patients with skull-base low-grade chondrosarcoma and chordoma patients treated with pencil beam scanning proton therapy. Radiother Oncol. 2016;120(1):169–74. https://doi.org/10.1016/j.radonc.2016.05.011.

    Article  Google Scholar 

  23. Fung V, Calugaru V, Bolle S, et al. Proton beam therapy for skull base chordomas in 106 patients: a dose adaptive radiation protocol. Radiother Oncol. 2018;128(2):198–202.

    Article  Google Scholar 

  24. Mizoe JE, Hasegawa A, Takagi R, Bessho H, Onda T, Tsujii H. Carbon ion radiotherapy for skull base chordoma. Skull Base. 2009;19(3):219–24.

    Article  Google Scholar 

  25. Uhl M, Mattke M, Welzel T, et al. Highly effective treatment of skull base chordoma with carbon ion irradiation using a raster scan technique in 155 patients: first long-term results. Cancer. 2014;120(21):3410–7.

    Article  Google Scholar 

  26. Deraniyagala RL, Yeung D, Mendenhall WM, et al. Proton therapy for skull base chordomas: an outcome study from the university of Florida proton therapy institute. J Neurol Surg B Skull Base. 2014;75:53–7.

    Article  Google Scholar 

  27. Noël G, Feuvret L, Calugaru V, et al. Chordomas of the base of the skull and upper cervical spine. One hundred patients irradiated by a 3D conformal technique combining photon and proton beams. Acta Oncol. 2005;44(7):700–8.

    Article  Google Scholar 

  28. Rosenberg AE, Nielsen GP, Keel SB, et al. Chondrosarcoma of the base of the skull: a clinicopathologic study of 200 cases with emphasis on its distinction from chordoma. Am J Surg Pathol. 1999;23:1370–8.

    Article  Google Scholar 

  29. Weber DC, Badiyan S, Malyapa R, et al. Long-term outcomes and prognostic factors of skull-base chondrosarcoma patients treated with pencil-beam scanning proton therapy at the Paul Scherrer Institute. Neuro-Oncology. 2016;18:236–43.

    Article  Google Scholar 

  30. Weber DC, Murray F, Combescure C, Calugaru V, Alapetite C, Albertini F, et al. Long term outcome of skull-base chondrosarcoma patients treated with high-dose proton therapy with or without conventional radiation therapy. Radiother Oncol. 2018;129:520–6.

    Article  Google Scholar 

  31. Feuvret L, Bracci S, Calugaru V, et al. Efficacy and safety of adjuvant proton therapy combined with surgery for chondrosarcoma of the skull base: a retrospective, population-based study. Int J Radiat Oncol Biol Phys. 2016;95:312–21.

    Article  Google Scholar 

  32. Mattke M, Vogt K, Bougatf N, et al. High control rates of proton- and carbon-ion-beam treatment with intensity-modulated active raster scanning in 101 patients with skull base chondrosarcoma at the Heidelberg Ion Beam Therapy Center. Cancer. 2018;124(9):2036–44.

    Article  Google Scholar 

  33. Takagi M, Demizu Y, Nagano F, et al. Treatment outcomes of proton or carbon ion therapy for skull base chordoma: a retrospective study. Radiat Oncol. 2018;13(1):232.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Shanghai, China

    Lin Kong

  2. Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Fudan University Shanghai Cancer Center, Shanghai, China

    Jing Yang & Jiade J. Lu

Authors
  1. Lin Kong
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  2. Jing Yang
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  3. Jiade J. Lu
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Corresponding author

Correspondence to Jiade J. Lu .

Editor information

Editors and Affiliations

  1. Department of Radiation Oncology, University of Washington, Seattle, WA, USA

    Edward Kim

  2. Department of Radiation Oncology, University of Washington, Seattle, WA, USA

    Upendra Parvathaneni

  3. Department of Radiation Oncology, The Ohio State University James Cancer Center, Columbus, OH, USA

    Meng Xu Welliver

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Kong, L., Yang, J., Lu, J.J. (2022). Particle Therapy for Head and Neck Sarcomas. In: Kim, E., Parvathaneni, U., Welliver, M.X. (eds) Radiation Therapy for Sarcomas and Skin Cancers. Practical Guides in Radiation Oncology. Springer, Cham. https://doi.org/10.1007/978-3-031-06706-8_7

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  • DOI: https://doi.org/10.1007/978-3-031-06706-8_7

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-06705-1

  • Online ISBN: 978-3-031-06706-8

  • eBook Packages: MedicineMedicine (R0)

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