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Concurrent Chemoradiation Therapy for Soft Tissue Sarcoma

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Radiation Therapy for Sarcomas and Skin Cancers

Part of the book series: Practical Guides in Radiation Oncology ((PGRO))

Abstract

Soft tissue sarcoma (STS) represents a heterogeneous group of malignancies. Many patients are treated with wide local excision with or without radiation therapy and/or chemotherapy. Patients with large and/or high-grade tumors have a particularly high risk of disease recurrence. Concurrent chemoradiation therapy dually seeks to reduce the risk of local recurrence through radiosensitization and to reduce the risk of distant recurrence through eradication of micrometastatic disease. The following chapter reviews classic anthracycline-based CRT (concurrent chemoradiotherapy) paradigms and describes more modern data that demonstrates improved tolerability of these regimens using modern radiotherapy and supportive care techniques. New CRT regimens using immunotherapy and targeted systemic therapy agents that are currently being tested in multicenter prospective trials will also be explored.

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Spraker, M.B., Haarberg, S., Ellis, H., Van Tine, B.A. (2022). Concurrent Chemoradiation Therapy for Soft Tissue Sarcoma. In: Kim, E., Parvathaneni, U., Welliver, M.X. (eds) Radiation Therapy for Sarcomas and Skin Cancers. Practical Guides in Radiation Oncology. Springer, Cham. https://doi.org/10.1007/978-3-031-06706-8_6

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