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Hyaluronic Acid (Hyaluronan)

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Microbial Production of High-Value Products

Part of the book series: Microbiology Monographs ((MICROMONO,volume 37))

Abstract

Hyaluronic acid is one of the most valuable polysaccharides due to its enormous and unique biofunctionality in the human body, which renders it of highest interest for pharmaceutical and cosmeceutical applications. Within this chapter, we will give an overview of the development of hyaluronic acid as a commercial product, including the various origins, recombinant production, optimization of the production process as well as purification strategies. The main scope will be on microbial production of hyaluronic acid, the biosynthetic pathway, the different fermentation processes and strategies for overproduction, as well as optimized downstream processing. We will also give an overview of the commercial producers and their current production processes as well as the patents which are currently active in that field. In addition, we will present and discuss applications in the field of cosmetics, pharmaceuticals as well as material science. In sum, we will give a current and comprehensive overview of hyaluronic acid production in the year 2021.

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Meliawati, M., Gansbiller, M., Schmid, J. (2022). Hyaluronic Acid (Hyaluronan). In: Rehm, B.H.A., Wibowo, D. (eds) Microbial Production of High-Value Products. Microbiology Monographs, vol 37. Springer, Cham. https://doi.org/10.1007/978-3-031-06600-9_7

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