Abstract
The aim of this study is to assess the changes in imaging of dopamine transporters using [123]I-FP-CIT SPECT when applying a deformation of the striatum using a linear and/or a non-linear registration to a reference template. For that, the deformation has been indirectly measured studying the changes in the intensity values in two different scenarios when, during the interpolation stage, the amount or the concentrations of intensity values are preserved. As showed by our results, the degree of deformation is greater in images from patients with Parkinson’s Disease than in healthy control subjects.
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Acknowledgments
This work was supported by the MCIN/AEI/10.13039/501100011033/ and FEDER “Una manera de hacer Europa” under the RTI2018-098913-B100 project; by the Consejería de Economía, Innovación, Ciencia y Empleo (Junta de Andalucía) and FEDER under CV20-45250, A-TIC-080-UGR18, B-TIC-586-UGR20 and P20-00525 projects; and by the Ministerio de Universidades under the FPU18/04902 grant given to C. Jimenez-Mesa and the Margarita-Salas grant to J.E. Arco.
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Castillo-Barnes, D., Arco, J.E., Jimenez-Mesa, C., Ramirez, J., Górriz, J.M., Salas-Gonzalez, D. (2022). Evaluating Intensity Concentrations During the Spatial Normalization of Functional Images for Parkinson’s Disease. In: Ferrández Vicente, J.M., Álvarez-Sánchez, J.R., de la Paz López, F., Adeli, H. (eds) Artificial Intelligence in Neuroscience: Affective Analysis and Health Applications. IWINAC 2022. Lecture Notes in Computer Science, vol 13258. Springer, Cham. https://doi.org/10.1007/978-3-031-06242-1_18
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