Abstract
Infection in the diabetic foot is a unique clinical entity that correlates with increased risk of poor clinical outcomes, hospital admissions, lower extremity amputation and potentially life-threatening sepsis. Diabetic Foot Infections (DFI) are common and can present to any primary, secondary or tertiary care setting. Management requires multi-disciplinary input from diabetology, vascular surgery, podiatry and orthopaedic teams where needed. Diabetic patients are frequently multi-comorbid and so foot assessments can be forgotten. Monitoring with regular foot assessments enables early referral to a diabetic foot team and improved outcomes. A consistent evidence-based approach to the diagnosis and evaluation of DFI is useful for all clinicians to optimise care and avoid complications.
Considerations when approaching a Diabetic Foot Infection (DFI):
-
1.
Diagnosis: Is it infected? Definition and Challenges
-
2.
Clinical Evaluation: What is the Extent and Severity?
-
3.
Diagnostic Evaluation: Radiological and Microbiological considerations
-
4.
Management:
-
(a)
In-patient or out-patient management
-
(b)
Antibiotic choice
-
(c)
Intravenous or oral route
-
(d)
Duration of antimicrobial therapy
-
(e)
Need for surgery
-
(a)
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Boulton AJM, Armstrong DG, Kirsner RS, et al. Diagnosis and management of diabetic foot complications. Arlington: American Diabetes Association; 2018. p. 1–20.
Lipsky BA, Senneville E, Abbas ZG, et al.; IWGDF. Guideline on the diagnosis and treatment of foot infection in persons with diabetes. Diabetes Metab Res Rev. 2020;36 Suppl 1:e3280. iwgdfguidelies.org/wp-/uploads/2019/05/05-IWGDF-Infection-guideline-2019.pdf. Accessed 5 Nov 2019.
Lipsky BA, Berendt AR, Cornia PB, et al.; Infectious Diseases Society of America. 2012 Infectious Diseases Society of America clinical practice guideline for the diagnosis and treatment of diabetic foot infections. Clin Infect Dis. 2012;54:e132–e173.
Grayson LM, et al. Kucers’ the use of antibiotics, sixth edition. 100, 221, 238, 268, 351, 500, 569, 601, 621, 851, 895, 987, 1076, 1211.
Lauri C, Leone A, et al. Diabetic foot infections: the diagnostic challenges. J Clin Med. 2020;9:1779.
Tawfik GM, Dibas M, et al. Concordance of bone and non bone specimens in microbiological diagnosis of osteomyelitis: a systematic review and meta-analysis. J Infect Public Health. 2020;13:1682–93.
Madani DK, Saeed MA, et al. The role of remnant bone microbiological cultures in managing diabetic foot osteomyelitis. Br J Diabetes, original article.
Boulton AJM, Armstrong DG, Kirsner RS, et al. Diagnosis and management of diabetic foot infections. Arlington: American Diabetes Association; 2020. p. 1–24.
Thanit AK, Fatana D, et al. Antibiotic penetration into bone and joins: an update review. Int J Infect Dis. 2019;81:128–36.
Li HK, Rombach I, Zambellas R, et al.; OVIVA Trial Collaborators. Oral versus intravenous antibiotics for bone and joint infection. N Engl J Med. 2019;380:425–436.
Gariani K, Lebowitz D, et al. Remission in diabetic foot infections: duration of antibiotic therapy and other possible associated risk factors; diabetes. Obes Metab. 2019;21(2):244–51.
Kim B-N, Kim ES, Oh M-D. Oral antibiotic treatment of staphylococcal bone and joint infections in adults. J Antimicrob Chemother. 2014;69:309–22.
Acknowledgments
I would like to thank Dr. Colin Macloed and Dr. James Barnacle for their help with review and proofreading of the chapter.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this chapter
Cite this chapter
Pathiraja, M.M. (2023). Diagnosis and Management of Diabetic Foot Infections. In: Shearman, C.P., Chong, P. (eds) Management of Diabetic Foot Complications. Springer, Cham. https://doi.org/10.1007/978-3-031-05832-5_7
Download citation
DOI: https://doi.org/10.1007/978-3-031-05832-5_7
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-031-05831-8
Online ISBN: 978-3-031-05832-5
eBook Packages: MedicineMedicine (R0)