Skip to main content
SpringerLink
Log in

Mechanical Circulatory Support in the Era of COVID-19

  • Chapter
  • First Online:
A Guide to Mechanical Circulatory Support

Abstract

In December 2019, a viral pneumonia with unique characteristics first appeared in the Wuhan province of China at alarmingly growing rates of infection and severity of illness. Polymerase chain reaction (PCR) testing revealed the virus was of the coronavirus family however unique to other forms and subsequently named 2019-novel coronavirus (SARS-CoV-2). The World Health Organization (WHO) declared a global pandemic in March 2020 after the virus began spreading across Europe and into the United States. Treatment with conventional therapies were found to be ineffective and high rates of global morbidity and mortality were noted. Vaccines were developed by the end of 2020 for preventative therapy. Since the first identification of this virus, mutations have developed creating multiple variants creating fluctuations in waves of disease and remissions. This chapter reviews the global experience with SARS-CoV2 and the relationship to ventricular assist device (VAD) care.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 69.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 89.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Singh R, Domenico C, Rao SD, Urgo K, Prenner SB, Wald JW, et al. Novel coronavirus disease 2019 in a patient on durable left ventricular assist device support. J Card Fail. 2020;26(5):438–9.

    Article  Google Scholar 

  2. Jiang F, Deng L, Zhang L, Cai Y, Chen C, et al. Review of the clinical characteristics of coronavirus disease 2019 (COVID-19). J Gen Intern Med. 2020;35(3):1545–9.

    Article  Google Scholar 

  3. Wu Y-C, Chen C-S, Chan Y-J. The outbreak of COVID-19: an overview. J Chin Med Assoc. 2020;83(3):217–20. https://doi.org/10.1097/JCMA.0000000000000270.

    Article  CAS  Google Scholar 

  4. Coronavirus disease (COVID-19). n.d. https://www.who.int/emergencies/diseases/novel-coronavirus2019?gclid=CjwKCAjw9MuCBhBUEiwAbDZ-7hoW1jT6AUi_r61Uxt5Gw9R_Z_lB5dERn89K0KAiBRuPc55tCPZrxoCIuAQAvD_BwE. Retrieved 18 Mar 2021.

  5. Velavan TP, Meyer CG. The COVID-19 epidemic. Tropical Med Int Health. 2020;25(3):278–80. https://doi.org/10.1111/tmi.13383.

    Article  CAS  Google Scholar 

  6. Beigel JH, Tomashek KM, Dodd LE, Mehta AK, Zingman BS, Kalil AC, et al. Remdesivir for the treatment of Covid-19—final report. N Engl J Med. 2020;383(19):1813–26. https://doi.org/10.1056/nejmoa2007764.

    Article  CAS  Google Scholar 

  7. Ejaz H, Alsrhani A, Zafar A, Javed H, Junaid K, Abdalla AE, et al. Covid-19 and comorbidities: deleterious impact on infected patients. J Infect Public Health. 2020;13:1833–9. https://doi.org/10.1016/j.jiph.2020.07.014.

    Article  Google Scholar 

  8. Awad WI, Bashir M. Mechanical circulatory support—challenges, strategies, and preparations. J Card Surg. 2021;36:1723. https://doi.org/10.1111/jocs.15301.

    Article  Google Scholar 

  9. Bozkurt B, Kovacs R, Harrington B. HFSA/ACC/AHA statement addresses concerns re: using RAAS antagonists in COVID-19. 2020.

    Google Scholar 

  10. Badulak J, Antonini MV, Stead CM, Shekerdemian L, Raman L, Paden ML, Agerstrand C, Bartlett RH, Barrett N, Combes A, Lorusso R, Mueller T, Ogino MT, Peek G, Pellegrino V, Rabie AA, Salazar L, Schmidt M, Shekar K, MacLaren G, Brodie D. ECMO for COVID-19. ASAIO J. 2021 (Online First). https://doi.org/10.1097/MAT.0000000000001422.

  11. Davis CR, Beeson T. Mitigating pressure injury challenges when placing patients in a prone position. J Wound Ostomy Contin Nurs. 2020;47(4):326–7. https://doi.org/10.1097/won.0000000000000665.

    Article  Google Scholar 

  12. Rubin D, Chan-Tack K, Farley J, Sherwat A. FDA approval of Remdesivir—a step in the right direction. N Engl J Med. 2020;383(27):2598–600. https://doi.org/10.1056/nejmp2032369.

    Article  CAS  Google Scholar 

  13. Rossi M, Serraino G, Jiritano F, Renzulli A. What is the optimal anticoagulation in patients with a left ventricular assist device? Oct 2012. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3445379/. Retrieved 16 Apr 2021.

  14. Manigaba K, Hawks J, Kima M. Remdesivir-warfarin interaction: a case report. n.d. https://scholarlycommons.hcahealthcare.com/hcahealthcarejournal/vol1/iss0/15/. Retrieved 16 Apr 2021.

  15. Jahanshahlu L, Rezaei N. Monoclonal antibody as a potential anti-COVID-19. Biomed Pharmacother. 2020;129:110337. https://doi.org/10.1016/j.biopha.2020.110337. Epub 2020 Jun 4.

    Article  CAS  Google Scholar 

  16. Commissioner O. Coronavirus (covid-19) update: FDA authorizes monoclonal antibody for treatment of covid-19. n.d. https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-authorizes-monoclonal-antibody-treatment-covid-19. Retrieved 15 Apr 2021.

  17. Commissioner O. Coronavirus (covid-19) update: FDA authorizes monoclonal antibodies for treatment of covid-19. n.d. https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-authorizes-monoclonal-antibodies-treatment-covid-19. Retrieved 15 Apr 2021.

  18. Rogers L, JH Bloomberg School of Public Health. An update on COVID-19 treatments: monoclonal antibodies, convalescent plasma, and other promising developments. 20 Nov 2020. https://www.jhsph.edu/covid-19/articles/an-update-on-covid-19-treatments-monoclonalantibodies-convalescent-plasma-and-other-promising-developments.html. Retrieved 19 Mar 2021.

  19. Corticosteroids. n.d. Understanding mRNA COVID-19 vaccines | CDC. https://www.covid19treatmentguidelines.nih.gov/immunomodulators/corticosteroids/#:~:text=Patients%20with%20severe%20COVID%2D19,or%20mitigate%20these%20deleterious%20effects. Retrieved 7 Apr 2021.

  20. Understanding mRNA covid-19 vaccines. n.d. https://www.cdc.gov/coronavirus/2019-ncov/vaccines/different-vaccines/mrna.html. Retrieved 16 Apr 2021.

  21. Understanding viral vector covid-19 vaccines. n.d. https://www.cdc.gov/coronavirus/2019-ncov/vaccines/different-vaccines/viralvector.html. Retrieved 16 Apr 2021.

  22. Pinho A. AstraZeneca’s COVID-19 vaccine: EMA finds possible link to very rare cases of unusual blood clots with low platelets. 8 Apr 2021. https://www.ema.europa.eu/en/news/astrazenecas-covid-19-vaccine-ema-finds-possible-linkvery-rare-cases-unusual-blood-clots-low-blood. Retrieved 16 Apr 2021.

  23. Centers for Disease Control and Prevention. CDC expands eligibility for covid-19 booster shots. Centers for Disease Control and Prevention. 21 Oct 2021. https://www.cdc.gov/media/releases/2021/p1021-covid-booster.html. Retrieved 28 Oct 2021.

  24. Stewart S, Silber D, Kim B, Satya K, Batsides G, Mody K, Anderson M. Implantation of durable VAD during Covid-19: an epicenter experience. Int J Clin Cardiol. 2020;7(6) https://doi.org/10.23937/2378-2951/1410206.

  25. Rosenbaum L. The untold toll—the pandemic’s effects on patients without covid-19. N Engl J Med. 2021. https://www.nejm.org/doi/full/10.1056/EJMms2009984. Retrieved 16 Apr 2021.

  26. Graham J. Coronavirus patients caught in conflict between hospital and nursing homes. 30 Mar 2020. https://khn.org/news/coronavirus-patientscaught-in-conflict-between-hospital-and-nursing-homes/. Retrieved 16 Apr 2021.

  27. Dionizovik-Dimanovski M, Levin AP, Fried J, Mody KP, Simonich E, Garan AR, Yuzefpolskaya M, Takayama H, Naka Y, Colombo PC, Kalesan B, Uriel N, Jorde UP. Correlation between home INR and core laboratory INR in patients supported with continuous-flow left ventricular assist devices. ASAIO J. 2015;61(4):386–90. https://doi.org/10.1097/MAT.0000000000000229.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Hackensack University Medical Center, Hackensack, NJ, USA

    Christina Marie Silva & Scott Stewart

Authors
  1. Christina Marie Silva
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Scott Stewart
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Scott Stewart .

Editor information

Editors and Affiliations

  1. Hackensack University Medical Center, Hackensack, NJ, USA

    Scott Stewart

  2. UAB Hospital, University of Alabama at Birmingham, Birmingham, AL, USA

    Peggy Blood

Rights and permissions

Reprints and permissions

Copyright information

© 2022 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Silva, C.M., Stewart, S. (2022). Mechanical Circulatory Support in the Era of COVID-19. In: Stewart, S., Blood, P. (eds) A Guide to Mechanical Circulatory Support. Springer, Cham. https://doi.org/10.1007/978-3-031-05713-7_21

Download citation

  • DOI: https://doi.org/10.1007/978-3-031-05713-7_21

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-05712-0

  • Online ISBN: 978-3-031-05713-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation