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Vaccination with Live Vaccines

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Vaccination of Immunosuppressed Children in Clinical Practice

Part of the book series: In Clinical Practice ((ICP))

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Abstract

In this chapter, we discuss the challenge of vaccinating immunocompromised individuals with live-attenuated vaccine, which are mostly contraindicated given the fear of a theoretical uncontrolled replication that could lead to severe vaccine-induced disease. We present the safety and immunogenicity data available on measles-mumps-rubella (MMR) vaccine, varicella vaccine, or any other live-attenuated vaccine in children with rheumatic diseases, solid organ transplant (SOT), or hematopoietic stem cell transplant. We show that there is increasing evidence to suggest that MMR and varicella vaccines are well tolerated in individuals with mild immunosuppression, liver or kidney transplant recipients (strict conditions), after hematopoietic stem cell transplantation, or in individuals with dysimmune disorders on low/no immunosuppressant therapy. As both vaccines have the potential to protect patients against threatening pathogens that are endemic or linked to epidemics worldwide, we discuss the current guidelines for MMR vaccine and varicella vaccine in the various imuunosuppressive conditions. We also provide a brief overview on the data available on live-attenuated vaccine following treatment with intravenous immunoglobulin or in infants born to mothers who received immunosuppressive treatment during pregnancy.

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  1. Division of General Paediatrics, Immunology-Vaccinology, Geneva University Hospitals, Geneva, Switzerland

    Geraldine Blanchard-Rohner & Laure F. Pittet

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  1. Geraldine Blanchard-Rohner
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Correspondence to Geraldine Blanchard-Rohner .

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Blanchard-Rohner, G., Pittet, L.F. (2022). Vaccination with Live Vaccines. In: Vaccination of Immunosuppressed Children in Clinical Practice . In Clinical Practice. Springer, Cham. https://doi.org/10.1007/978-3-031-04844-9_3

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