Abstract
The recent development of mapping technologies, such as Hi-C, that probes the 3D genome organization reveals that a chromosome is divided into topologically associating domains (TADs). TADs are genomic regions where chromatin loci are more frequently interacting with chromatin loci from the same TADs rather than from other TADs. TADs are functional units for transcriptional regulation, such as constraining interactions between enhancers and promoters.
D. Hua, M. Gu and Y. Du—These three authors contributed equally.
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Hua, D. et al. (2022). DiffDomain Enables Identification of Structurally Reorganized Topologically Associating Domains. In: Pe'er, I. (eds) Research in Computational Molecular Biology. RECOMB 2022. Lecture Notes in Computer Science(), vol 13278. Springer, Cham. https://doi.org/10.1007/978-3-031-04749-7_20
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DOI: https://doi.org/10.1007/978-3-031-04749-7_20
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